Aloe-emodin

Aloe-emodin is a hydroxyanthraquinone found in Aloe vera leaves that has potent laxative action by inducing chloride secretion in colonic mucosa and releasing acetylcholine, which stimulates contraction of intestinal smooth muscle. It also demonstrates anti-tumor activity (ED50s = 1-13 µM), inducing apoptosis in various cancer cells by increasing the production of reactive oxygen species. Aloe-emodin is reported to have estrogenic activity as a phytoestrogen and has been shown to inhibit breast cancer cell proliferation by downregulating ERalpha protein levels, and thus, suppressing transcriptional activation of the receptor.Formal Name: 1,8-dihydroxy-3-(hydroxymethyl)-9,10-anthracenedione. CAS Number: 481-72-1. Synonyms: 3-Hydroxymethylchrysazine, NSC 38628, Rhabarberone. Molecular Formula: C15H10O5. Formula Weight: 270.2. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 5 mg/ml, DMSO: 2 mg/ml. lambdamax: 225, 255, 285, 430 nm. SMILES: O=C1C2=CC(CO)=CC(O)=C2C(C3=C1C=CC=C3O)=O. InChi Code: InChI=1S/C15H10O5/c16-6-7-4-9-13(11(18)5-7)15(20)12-8(14(9)19)2-1-3-10(12)17/h1-5,16-18H,6H2. InChi Key: YDQWDHRMZQUTBA-UHFFFAOYSA-N. Origin: Plant/Aloe barbadensis.