AK-7

The sirtuin SIRT2 is a deacetylase which targets alpha-tubulin, histone 4, forkhead transcription factors, and several other substrates. It has roles in metabolic diseases, cancer, age-related disorders, and neurodegenerative diseases, potentially including Alzheimer's, Huntington's, and Parkinson's diseases. AK-7 is a cell- and brain-permeable inhibitor of SIRT2 (IC50 = 15.5 µM). In culture, it diminishes neuronal cell death induced by mutant huntingtin fragment. In addition, AK-7 down-regulates cholesterol biosynthetic gene expression and reduces total cholesterol levels in neurons in vivo.Formal Name: N-(3-bromophenyl)-3-[(hexahydro-1H-azepin-1-yl)sulfonyl]-benzamide. CAS Number: 420831-40-9. Molecular Formula: C19H21BrN2O3S. Formula Weight: 437.4. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 15 mg/ml, DMF:PBS (pH 7.2) (1:2): 0.3 mg/ml, DMSO: 5 mg/ml, Ethanol: 1 mg/ml. lambdamax: 269 nm. SMILES: O=C(NC1=CC(Br)=CC=C1)C2=CC(S(N3CCCCCC3)(=O)=O)=CC=C2. InChi Code: InChI=1S/C19H21BrN2O3S/c20-16-8-6-9-17(14-16)21-19(23)15-7-5-10-18(13-15)26(24,25)22-11-3-1-2-4-12-22/h5-10,13-14H,1-4,11-12H2,(H,21,23). InChi Key: IYAYHZZWYNXHEQ-UHFFFAOYSA-N.