AdipoRon . HCl (water soluble)

White solid. Highly soluble in DMSO. Soluble in 100% ethanol or methanol. Slightly soluble in water (1mg/ml). Orally-active adiponectin receptor (AdipoR) agonist. Binds to AdipoR1 and AdipoR2 at low &mu,m concentration, Activates 5'-adenosine monophosphate-activated protein kinase (AMPK) in cultured mammalian cells, Activates peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC1alpha) which boosts mitochondrial proliferation and energy metabolism, Improves diabetes, glucose and lipid metabolism and insulin sensitivity in cultured cells and in mice by AdipoR-dependent mechanisms, Rescued the shortened lifespan of db/db mice (AdipoRs KO) on high-fat diet, Reduces expression levels of genes encoding inflammatory cytokines such as TNF-alpha, IL-6 and CCL-2 in WAT of WT mice but not db/db mice.