Adenosine-5'-O-diphospho-(1''-(4-nitrophenoxy)-ribose) (sodium salt)

Adenosine-5'-O-diphospho-(1''-(4-nitrophenoxy)-ribose) is a nitrophenyl ribose-modified nucleotide and colorimetric substrate for poly(ADP-ribose) polymerase 1 (PARP1). PARP1 binds and hydrolyzes adenosine-5'-O-diphospho-(1''-(4-nitrophenoxy)-ribose) to release p-nitrophenol, which can be quantified by colorimetric detection at 405 nm as a measure of PARP1 activity.Formal Name: adenosine 5'-(trihydrogen diphosphate), P'->5-ester with 4-nitrophenyl beta-D-ribofuranoside, disodium salt. Synonyms: ADP-ribose-pNP, ADPR-pNP. Molecular Formula: C21H24N6O16P2 . 2Na. Formula Weight: 724.4. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: Water: Soluble. SMILES: O=P(OP(OC[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C=NC3=C(N)N=CN=C32)O1)([O-])=O)([O-])OC[C@@H]4[C@@H](O)[C@@H](O)[C@H](OC5=CC=C([N+]([O-])=O)C=C5)O4.[Na+].[Na+]. InChi Code: InChI=1S/C21H26N6O16P2.2Na/c22-18-13-19(24-7-23-18)26(8-25-13)20-16(30)14(28)11(41-20)5-38-44(34,35)43-45(36,37)39-6-12-15(29)17(31)21(42-12)40-10-3-1-9(2-4-10)27(32)33,,/h1-4,7-8,11-12,14-17,20-21,28-31H,5-6H2,(H,34,35)(H,36,37)(H2,22,23,24),,/q,2*+1/p-2/t11-,12-,14-,15-,16-,17-,20-,21-,,/m1../s1. InChi Key: NQOVHENPPPWLBJ-AKTZONNESA-L.