ACY-775

Off white solid. Soluble in DMSO, methanol or ethanol. Cell permeable, potent and selective class IIb HDAC6 inhibitor (IC50 =7.5nM). Displays high selectivity over HDAC1-9 (IC50=1-10µ,M), Shows improved brain bioavailability compared to tubastatin A (Prod. No. AG-CR1-3900), Induces hyperacetylation of alpha-tubulin in brain without concurrently altering the acetylation of histones, Shows antidepressant activity, HDAC6 deacetylates tubulin, HSP90 and the core histones (H2A, H2B, H3, H4). Histone deacetylases act via the formation of large multiprotein complexes. HDAC6 plays an important role in microtubule-dependent cell motility, transcriptional regulation, degradation of misfolded proteins and cell cycle and is involved in autophagy, inflammation, cancer and neurodegeneration.