160 products were found matching "K11407"!

Active human HDAC6, GenBank Accession No. BC069243, full length with N-terminal GST tag, MW= 159 kDa, expressed in baculovirus expression system.

MPT0G211 is an inhibitor of histone deacetylase 6 (HDAC6, IC50 = 0. nM). It is selective for HDAC6 over HDAC1-5 (IC50s = 9. 12. 7. 4. and 3. µM, respectively), HDAC7-11 (IC50s = 0. 1. 1. 9. and 0. µM, respectively), and sirtuin 1 (SIRT1, IC50 = > 20 µM), as well as a panel of 97 kinases at 1 µM. MPT0G211 inhibits...

Nrf2 activation of the antioxidant response element (ARE) is central to cytoprotective gene expression against oxidative and/or electrophilic stress. Unless activated by inflammatory, environmental, or oxidative stressors, Nrf2 is sequestered in the cytoplasm by its repressor, Keap1. Because of its protective...

An HDAC6 inhibitor (IC50 = 3 nM), increases the levels of acetylated alpha-tubulin in SK-N-BE(2) cells in a concentration-dependent manner, prevents cisplatin-induced decreases in mitochondrial OCR and mitochondrial motility in tibial nerves isolated from mice at 10 mg/kg per day, inhibits cisplatin-induced...

An HDAC6 inhibitor (IC50 = 7.1 nM), selective for HDAC6 over ten other HDAC isoforms (IC50s = 3.46-32.8 µM), ) increases the levels of acetylated alpha-tubulin in HEK293 cells at 10 µM, prevents deficits in the novel object recognition test in Fmrp knockout mice at 20 mg/kg twice per day

Protein function: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone...

Histone deacetylase 6 (HDAC6) is a class II HDAC that represses transcription by removing acetyl groups from histones. In addition, HDAC6 deacetylases tubulin, which is important in regulating microtubule stability and function. CAY10603 is a potent and selective inhibitor of HDAC6 (IC50 = 0.002 nM, as compared with...

Tubacin is a tubulin acetylation inducer that selectively inhibits histone deacetylase (HDAC) 6 (IC50 = 4 nM). In comparison, it demonstrates at least 300-fold selectivity against all other HDAC isoforms (IC50s range from 1.3-17.3 µM). Tubacin induces alpha-tubulin hyperacetylation at 2.5 µM in primary cortical...

Tubastatin A is a potent HDAC6 inhibitor with an IC50 value of 15 nM. Comparatively, it demonstrates over 1,000-fold selectivity against all other HDAC isoforms (IC50s > 16 µM), excluding HDAC8 (IC50 = 0.9 µM). Tubastatin A induces alpha-tubulin hyperacetylation at 2.5 µM in primary cortical neuron cultures. In a...

Human HDAC6 (GenBank Accession No. NM_006044), full length with C-terminal Flag tag, MW= 132 kDa, expressed in baculovirus expression system. Protein was purified by affinity chromatography and gel filtration. Assay condition: 25 mM Tris/HCl, pH 8.0, 137 mM NaCl, 2.7 mM KCl, 1 mM MgCl2, and 0.1 mg/ml BSA, 30 µM BPS...

ACY-1215 is an inhibitor of the class IIb histone deacetylase (HDAC) HDAC6 (IC50 = 0.0047 µM). It is selective for HDAC6 over the class I HDACs HDAC1, -2, -3, and -8 (IC50s = 0.058, 0.048, 0.051, and 0.1 µM, respectively), class IIa HDACs HDAC4, -5, -7, and -9 (IC50s = 7, 5, 1.4 and >10 µM, respectively), class III...

HDAC6 is a Class II HDAC that can shuttle between the nucleus and cytoplasm, suggesting potential extranuclear functions by regulating the acetylation status of non-histone substrates. By modifying chromatin structure and other non-histone proteins, HDACs play important roles in controlling complex biological...