165 products were found matching "K11407"!

Active human HDAC6, GenBank Accession No. BC069243, full length with N-terminal GST tag, MW= 159 kDa, expressed in baculovirus expression system.

Mz325 is a dual inhibitor of histone deacetylase 6 (HDAC6) and sirtuin 2 (SIRT2, IC50s = 0.043 and 0.32 µM, respectively, in a cell-free assay). Mz325 is a heterobifunctional molecule that contains an HDAC6 inhibitor conjugated to a SIRT2 inhibitor via a triazole linker. It is selective for HDAC6 and SIRT2 over...

Nrf2 activation of the antioxidant response element (ARE) is central to cytoprotective gene expression against oxidative and/or electrophilic stress. Unless activated by inflammatory, environmental, or oxidative stressors, Nrf2 is sequestered in the cytoplasm by its repressor, Keap1. Because of its protective...

MPT0G211 is an inhibitor of histone deacetylase 6 (HDAC6, IC50 = 0. nM). It is selective for HDAC6 over HDAC1-5 (IC50s = 9. 12. 7. 4. and 3. µM, respectively), HDAC7-11 (IC50s = 0. 1. 1. 9. and 0. µM, respectively), and sirtuin 1 (SIRT1, IC50 = > 20 µM), as well as a panel of 97 kinases at 1 µM. MPT0G211 inhibits...

Protein function: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone...

Histone deacetylase 6 (HDAC6) is a class II HDAC that represses transcription by removing acetyl groups from histones. In addition, HDAC6 deacetylases tubulin, which is important in regulating microtubule stability and function. CAY10603 is a potent and selective inhibitor of HDAC6 (IC50 = 0.002 nM, as compared with...

An HDAC6 inhibitor (IC50 = 3 nM), increases the levels of acetylated alpha-tubulin in SK-N-BE(2) cells in a concentration-dependent manner, prevents cisplatin-induced decreases in mitochondrial OCR and mitochondrial motility in tibial nerves isolated from mice at 10 mg/kg per day, inhibits cisplatin-induced...

Human HDAC6 (GenBank Accession No. NM_006044), full length with C-terminal Flag tag, MW= 132 kDa, expressed in baculovirus expression system. Protein was purified by affinity chromatography and gel filtration. Assay condition: 25 mM Tris/HCl, pH 8.0, 137 mM NaCl, 2.7 mM KCl, 1 mM MgCl2, and 0.1 mg/ml BSA, 30 µM BPS...

ACY-1215 is an inhibitor of the class IIb histone deacetylase (HDAC) HDAC6 (IC50 = 0.0047 µM). It is selective for HDAC6 over the class I HDACs HDAC1, -2, -3, and -8 (IC50s = 0.058, 0.048, 0.051, and 0.1 µM, respectively), class IIa HDACs HDAC4, -5, -7, and -9 (IC50s = 7, 5, 1.4 and >10 µM, respectively), class III...

HDAC6 is a Class II HDAC that can shuttle between the nucleus and cytoplasm, suggesting potential extranuclear functions by regulating the acetylation status of non-histone substrates. By modifying chromatin structure and other non-histone proteins, HDACs play important roles in controlling complex biological...

The Fluorogenic HDAC3 Assay Kit is a complete assay system designed to measure HDAC6 activity for screening and profiling applications. It comes in a convenient 96-well format, with all the reagents necessary for 100 fluorescent HDAC6 activity measurements. In addition, the kit includes purified HDAC6 enzyme and the...

Description: Sulforaphane is a natural isothiocyanate that activates Nrf2 and inhibits AMPK-dependent signaling. Sulforaphane has antitumor and anti-inflammatory activities by increasing the transcription of tumor suppressor proteins and inhibiting histone deacetylase activity. Target: Nrf2, HDAC, Apoptosis....