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ACY-775
ACY-775

Item number: AG-CR1-3903-M001

Off white solid. Soluble in DMSO, methanol or ethanol. Cell permeable, potent and selective class IIb HDAC6 inhibitor (IC50 =7.5nM). Displays high selectivity over HDAC1-9 (IC50=1-10µ,M), Shows improved brain bioavailability compared to tubastatin A (Prod. No. AG-CR1-3900), Induces hyperacetylation of...
Keywords: 2-((1-(3-Fluorophenyl)cyclohexyl)amino)-N-hydroxypyrimidine-5-carboxamide
Application: HDAC6 inhibitor
CAS 1375466-18-4
MW: 330,4 D
From 160.00€ *
Review
ACY-775
ACY-775

Item number: Cay29198-1

ACY-775 is an inhibitor of histone deacetylase 6 (HDAC6, IC50 = 0.0075 µM). It is selective for HDAC6 over HDAC1, HDAC2, and HDAC3 (IC50s = 2.1, 2.5, and 11.2 µM, respectively). ACY-775 (2.5 µM) increases alpha-tubulin acetylation at lysine 40 in RN46A-B14 serotonergic cells. It increases the distance traveled in...
Keywords: 2-[[1-(3-fluorophenyl)cyclohexyl]amino]-N-hydroxy-5-pyrimidinecarboxamide
Application: HDAC6 inhibitor
CAS 1375466-18-4
MW: 330.4 D
From 44.00€ *
Review