ACY-775

ACY-775 is an inhibitor of histone deacetylase 6 (HDAC6, IC50 = 0.0075 µM). It is selective for HDAC6 over HDAC1, HDAC2, and HDAC3 (IC50s = 2.1, 2.5, and 11.2 µM, respectively). ACY-775 (2.5 µM) increases alpha-tubulin acetylation at lysine 40 in RN46A-B14 serotonergic cells. It increases the distance traveled in the center of the open field test and decreases immobility time in the tail suspension test, indicating anxiolytic- and antidepressant-like activities, respectively, in mice when administered at a dose of 50 mg/kg.Formal Name: 2-[[1-(3-fluorophenyl)cyclohexyl]amino]-N-hydroxy-5-pyrimidinecarboxamide. CAS Number: 1375466-18-4. Molecular Formula: C17H19FN4O2. Formula Weight: 330.4. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMF: 20 mg/ml, DMF:PBS (pH 7.2) (1:4): 0.2 mg/ml, DMSO: 15 mg/ml, Ethanol: 3 mg/ml. lambdamax: 269 nm. SMILES: O=C(NO)C1=CN=C(NC2(C3=CC=CC(F)=C3)CCCCC2)N=C1. InChi Code: InChI=1S/C17H19FN4O2/c18-14-6-4-5-13(9-14)17(7-2-1-3-8-17)21-16-19-10-12(11-20-16)15(23)22-24/h4-6,9-11,24H,1-3,7-8H2,(H,22,23)(H,19,20,21). InChi Key: IYBURCQQEUNLDL-UHFFFAOYSA-N.