Acetohydroxamic Acid

Acetohydroxamic acid (AHA) is an irreversible inhibitor of urease and a derivative of hydroxyurea (Cay-23725). It inhibits the growth of struvite crystals produced by P. mirabilis in artificial urine and the growth of H. pylori in vitro (MICs = 200 and 400 mg/L for various isolates of H. pylori). Chronic AHA administration in dogs dose-dependently reduces urine urease activity, pH, and crystalluria and inhibits growth of bladder stones. It also decreases gastritis, gastric lesions, and bacterial infection rates in Mongolian gerbils when administered at 2,500 ppm/animal following H. pylori infection. Formulations containing AHA have been used in the treatment of urinary tract infections.Formal Name: N-hydroxy-acetamide. CAS Number: 546-88-3. Synonyms: AHA, NSC 5073, NSC 176136, NSC 408425. Molecular Formula: C2H5NO2. Formula Weight: 75.1. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: Methanol: Slightly Soluble, Water: Slightly Soluble. SMILES: ONC(C)=O. InChi Code: InChI=1S/C2H5NO2/c1-2(4)3-5/h5H,1H3,(H,3,4). InChi Key: RRUDCFGSUDOHDG-UHFFFAOYSA-N.