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Acetaminophen is an analgesic and antipyretic compound. Unlike many NSAIDs, which inhibit both... more
Product information "Acetaminophen"
Acetaminophen is an analgesic and antipyretic compound. Unlike many NSAIDs, which inhibit both COX-1 and COX-2, early studies suggested that acetaminophen is a poor inhibitor of both isoforms. However, it does inhibit COX-2 by 83% and COX-1 by 56% in human blood ex vivo, albeit at a high 1,000 mg dose, with IC50 values of 25.8 and 113.7 µM, respectively. Acetaminophen is enzymatically and non-enzymatically converted to several reactive metabolites that contribute to adverse or indirect effects, including liver injury. At toxic doses, the acetaminophen metabolite N-acetyl-4-benzoquinone imine (NAPQI, Cay-16115) depletes glutathione reserves in the liver, leading to an accumulation of NAPQI and subsequent hepatocyte necrosis. Acetaminophen decreases glutathione levels and reduces glutathione peroxidase activity in mice when administered at a dose of 250 mg/kg and induces ferroptotic cell death in primary mouse hepatocytes, an effect that can be blocked by the ferroptosis inhibitor ferrostatin-1 (Cay-17729). Acetaminophen has analgesic and antipyretic properties in animal models.Formal Name: N-(4-hydroxyphenyl)-acetamide. CAS Number: 103-90-2. Synonyms: 4-Acetamidophenol, APAP, 4'-Hydroxyacetanilide, NSC 3991, NSC 109028, Paracetamol. Molecular Formula: C8H9NO2. Formula Weight: 151.2. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 25 mg/ml, DMSO: 20 mg/ml, Ethanol: 25 mg/ml, PBS (pH 7.2): 2 mg/ml. lambdamax: 249 nm. SMILES: OC1=CC=C(NC(C)=O)C=C1. InChi Code: InChI=1S/C8H9NO2/c1-6(10)9-7-2-4-8(11)5-3-7/h2-5,11H,1H3,(H,9,10). InChi Key: RZVAJINKPMORJF-UHFFFAOYSA-N.
Keywords: | 4-Acetamidophenol, 4'-Hydroxyacetanilide, APAP, NSC 109028, NSC 3991, Paracetamol, N-(4-hydroxyphenyl)-acetamide |
Supplier: | Cayman Chemical |
Supplier-Nr: | 10024 |
Properties
Application: | Analgesic |
MW: | 151.2 D |
Formula: | C8H9NO2 |
Purity: | >98% |
Format: | Crystalline Solid |
Database Information
CAS : | 103-90-2| Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +20°C (International: -20°C) |
Signal Word: | Warning |
GHS Hazard Pictograms: |
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H Phrases: | H302 |
P Phrases: | P264, P270, P301+310, P330, P501 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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