This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the comfort when using this website, are used for direct advertising or to facilitate interaction with other websites and social networks, are only set with your consent.
Configuration
Technically required
These cookies are necessary for the basic functions of the shop.
"Allow all cookies" cookie
"Decline all cookies" cookie
CSRF token
Cookie preferences
Currency change
Customer-specific caching
FACT-Finder tracking
Individual prices
Selected shop
Session
Comfort functions
These cookies are used to make the shopping experience even more appealing, for example for the recognition of the visitor.
Note
Show the facebook fanpage in the right blod sidebar
Statistics & Tracking
Affiliate program
Conversion and usertracking via Google Tag Manager
ABX-465 is an HIV anti-replicative agent. It associates with the human cap-binding complex, a complex that processes pre-mRNA, and induces aberrant splicing in HIV pre-mRNA expressed from host-integrated viral DNA. It produces non-typical mRNA in primary peripheral blood mononuclear cells (PBMCs) from HIV-infected patients without disrupting normal cellular mRNA splicing when used at a concentration of 5 µM. ABX-465 increases the expression of the anti-inflammatory miR-124 in both uninfected and HIV-infected PBMCs at the same concentration. ABX-464 reduces the replication of seven HIV-1 mutant strains by 71-99% in HIV-infected primary PBMCs. In vivo, ABX-465 (20 mg/kg per day) reduces HIV RNA levels and losses of CD4+, CD8+, and CD4+/CD8+ T cells in isolated peritoneal cells, as well as limits the extent of viral rebound, in a humanized mouse model of HIV infection. It also prevents weight loss and decreased colon length, increases in colon lesion number and size, and the number of macrophage infiltrates into colon tissue in a mouse model of ulcerative colitis induced by dextran sodium sulfate (DSS, Cay-23250) when administered at a dose of 50 mg/kg per day.Formal Name: 8-chloro-N-[4-(trifluoromethoxy)phenyl]-2-quinolinamine. CAS Number: 1258453-75-6. Molecular Formula: C16H10ClF3N2O. Formula Weight: 338.7. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: Acetonitrile: Soluble, DMSO: Soluble. SMILES: FC(F)(OC1=CC=C(NC2=CC=C3C=CC=C(Cl)C3=N2)C=C1)F. InChi Code: InChI=1S/C16H10ClF3N2O/c17-13-3-1-2-10-4-9-14(22-15(10)13)21-11-5-7-12(8-6-11)23-16(18,19)20/h1-9H,(H,21,22). InChi Key: OZOGDCZJYVSUBR-UHFFFAOYSA-N.
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the usability of this website, serve for direct advertising or simplify interaction with other websites and social networks, will only be used with your consent.
More information