AA147

AA147 is an endoplasmic reticulum (ER) proteostasis regulator. It activates an activating transcription factor 6-dependent (ATF6-dependent) ER stress response element reporter and antioxidant response element reporter in HT22 hippocampal cells (EC50s = 3.6 and 3.92 µM, respectively) and protects against glutamate-induced cytotoxicity and prevents increases in reactive oxygen species (ROS) in HT22 cells when used at a concentration of 10 µM. AA147 (10 µM) reduces cell death induced by the unfolded protein response (UPR) activator tunicamycin and increases ER-associated protein degradation (ERAD) in neonatal rat ventricular myocytes. It reduces the myocardial, renal, and cerebral infarct size as a percentage of the area at risk in mouse models of ischemia-reperfusion injury induced by left anterior descending coronary artery (LAD) ligation, renal portal system occlusion, or middle cerebral artery occlusion (MCAO), respectively, when administered at a dose of 2 mg/kg. AA147 also prevents the production of non-structural protein 5 (NS5) in dengue virus-infected Huh7 cells (IC50 = ~1 µM).Formal Name: N-(2-hydroxy-5-methylphenyl)-benzenepropanamide. CAS Number: 393121-74-9. Molecular Formula: C16H17NO2. Formula Weight: 255.3. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMF: 10 mg/ml, DMSO: 10 mg/ml, Ethanol: 5 mg/ml. lambdamax: 211 nm. SMILES: OC1=C(NC(CCC2=CC=CC=C2)=O)C=C(C)C=C1. InChi Code: InChI=1S/C16H17NO2/c1-12-7-9-15(18)14(11-12)17-16(19)10-8-13-5-3-2-4-6-13/h2-7,9,11,18H,8,10H2,1H3,(H,17,19). InChi Key: AWHLTHOHBAGPMY-UHFFFAOYSA-N.