A-61603

The alpha1-adrenergic receptors are Gq protein-coupled receptors that play a key role in the modulation of sympathetic nervous system activity and are the site of action for therapeutic agents, such as antihypertensive drugs. A-61603 is a selective alpha1A-adrenergic receptor agonist that is at least 35-fold more potent at alpha1A receptor sites than at alpha1B or alpha1D. Activation of the alpha1A-adrenergic receptor by A-61603 has been reported to increase the frequency of spontaneous Ca2+ transients in rat ventricular myocytes in vitro (EC50 = 6.9 nM) much more potently than activation by phenylephrine (Cay-17205, EC50 = 2.3 µM).Formal Name: N-[5-(4,5-dihydro-1H-imidazol-2-yl)-5,6,7,8-tetrahydro-2-hydroxy-1-naphthalenyl]-methanesulfonamide, monohydrobromide. CAS Number: 107756-30-9. Molecular Formula: C14H19N3O3S . HBr. Formula Weight: 390.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMSO: 20 mg/ml, Ethanol: 1 mg/ml, PBS (pH 7.2): 10 mg/ml. SMILES: OC1=C(NS(C)(=O)=O)C2=C(C(C3=NCCN3)CCC2)C=C1.Br. InChi Code: InChI=1S/C14H19N3O3S.BrH/c1-21(19,20)17-13-10-3-2-4-11(14-15-7-8-16-14)9(10)5-6-12(13)18,/h5-6,11,17-18H,2-4,7-8H2,1H3,(H,15,16),1H. InChi Key: LRFLWCZMTGTUEP-UHFFFAOYSA-N.