A-438079 (hydrochloride)

A-438079 is a competitive antagonist of the nucleotide receptor P2X7 (pIC50 = 6.9). It inhibits both calcium flux and IL-1beta release mediated by P2X7 while not affecting the activity of other P2X receptors. A-438079 is effective in evaluating the role of P2X7 in nociception, oxidative stress, and apoptosis in cells and animals.Formal Name: 3-[[5-(2,3-dichlorophenyl)-1H-tetrazol-1-yl]methyl]-pyridine, monohydrochloride. CAS Number: 899431-18-6. Molecular Formula: C13H9Cl2N5 . HCl. Formula Weight: 342.6. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, DMSO:PBS(pH 7.2) (1:3): 0.33 mg/ml, Ethanol: 10 mg/ml. SMILES: ClC1=C(Cl)C=CC=C1C2=NN=NN2CC3=CN=CC=C3.Cl. InChi Code: InChI=1S/C13H9Cl2N5.ClH/c14-11-5-1-4-10(12(11)15)13-17-18-19-20(13)8-9-3-2-6-16-7-9,/h1-7H,8H2,1H. InChi Key: MBTJFFMIPPMRGR-UHFFFAOYSA-N.