A-1120

A-1120 is a non-retinoid retinol binding protein 4 (RBP4) antagonist (Ki = 8.3 nM for disruption of RBP4 binding to transthyretin). It is selective for RBP4 over cellular retinol binding protein 1 (CRBP1, IC50s = 0.09 and >30 µM, respectively, in radioligand binding assays), as well as a panel of G protein-coupled receptors, kinases, and enzymes. A-1120 (30 mg/kg) reduces serum levels of RBP4 and retinol in mice. It also inhibits retinal bisretinoid accumulation in the Abca4-/- mouse model of enhanced retinal lipofuscinogenesis-induced macular degeneration.Formal Name: 2-[[[4-[2-(trifluoromethyl)phenyl]-1-piperidinyl]carbonyl]amino]-benzoic acid. CAS Number: 1152782-19-8. Molecular Formula: C20H19F3N2O3. Formula Weight: 392.4. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: 100 mM, Ethanol: 25 mM. lambdamax: 226, 252 nm. SMILES: FC(F)(F)C1=CC=CC=C1C2CCN(C(NC3=C(C(O)=O)C=CC=C3)=O)CC2. InChi Code: InChI=1S/C20H19F3N2O3/c21-20(22,23)16-7-3-1-5-14(16)13-9-11-25(12-10-13)19(28)24-17-8-4-2-6-15(17)18(26)27/h1-8,13H,9-12H2,(H,24,28)(H,26,27). InChi Key: MEAQCLPMSVEOQF-UHFFFAOYSA-N.