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SKLB197
Item number: Cay45728-10
SKLB197 is an inhibitor of ataxia-telangiectasia and Rad3-related protein/kinase (ATR) (IC50 = 0.013 µM). It is selective for ATR over a panel of 402 other kinases (IC50s = >1 µM). SKLB197 reduces growth in cancer cell lines deficient in ataxia-telangiectasia mutated kinase (ATM, IC50s = 0.13-0.66 µM) to a greater...
| Keywords: | 2-(1H-indol-4-yl)-4-[(3R)-3-methyl-4-morpholinyl]-6-(1methyl-1H-pyrazol-5-yl)-quinazoline |
| Application: | ATR inhibitor |
| CAS | 2713577-16-1 |
| MW: | 424.51 D |
From 249.00€
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ARN3261
Item number: Cay45729-10
ARN3261 is an inhibitor of salt-inducible kinase 2 (SIK2). It induces apoptosis in OVCAR-8, SKOV3, and OC 316 ovarian cancer cells and inhibits growth in ten ovarian cancer cell lines (IC50s = 0.8-2.6 µM). ARN3261 enhances sensitivity to carboplatin (Cay13112) in both carboplatin-sensitive and -resistant ovarian...
| Keywords: | GRN-300, 3-(3,5-difluoro-2-methoxyphenyl)-5-[1[1-(methylsulfonyl)-4-piperidinyl]-1H-pyrazol-4-yl]-1H-pyrrolo[2,3-b]pyridine |
| Application: | SIK2 inhibitor |
| CAS | 1613711-28-6 |
| MW: | 487.53 D |
From 78.00€
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Bafilomycin A1 (solution)
Item number: Cay46024-1
Bafilomycin A1 is a bacterial metabolite that has been found in Streptomyces and has diverse biological activities. It is an inhibitor of vacuolar H+-ATPases (V-ATPases, Ki = 0.5 nM in N. crassa vacuolar membranes) and is greater than 1,000-fold selective for V-ATPases over Na+/K+-, Ca2+-, and H+-ATPases....
| Keywords: | NSC 381866,... |
| Application: | Bioactive bacterial metabolite |
| CAS | 88899-55-2 |
| MW: | 622.84 D |
From 248.00€
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Hericenone D
Item number: Cay39785-1
Hericenone D is a monoterpenoid originally isolated from H. erinaceum.. SMILES: C/C(C)=C\C(C/C(C)=C/CC1=C(C(C=O)=C(C=C1OC)COC(CCCCCCCCCCCCCCCCC)=O)O)=O. InChi Code:...
| Keywords: | octadecanoic acid, [4-[(2E)-3,7-dimethyl-5-oxo-2,6-octadien-1-yl]-2-formyl-3-hydroxy-5-methoxyphenyl]methyl ester |
| Application: | Monoterpenoid |
| CAS | 137592-04-2 |
| MW: | 598.85 D |
From 118.00€
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AZD 0022
Item number: Cay44625-500
AZD 0022 is an inhibitor of mutant K-RasG12D, the dominant K-Ras mutant in pancreatic ductal adenocarcinoma (PDAC).. SMILES: F[C@@H]1C[C@]2(COC3=NC(N4CC(N5)C=CC5C4)=C6C=C(F)[C@@]([C@@]7=CC(N)=CC(C=C8)=C7C(C#C)=C8F)=C(F)C6=N3)CCCN2C1. InChi Code:...
| Keywords: | (4R)-4-[4-(3,8-diazabicyclo[3.2.1]oct-6-en-3-yl)-6,8-difluoro-2-[[(2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl]meth... |
| Application: | K-RasG12D inhibitor |
| CAS | 2958627-18-2 |
| MW: | 614.65 D |
555.00€
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CFTR Corrector 11
Item number: Cay45309-10
CFTR corrector 11 a substituted isoxazole containing morpholino and methoxy-benzene moieties.. SMILES: COC1=CC=C(C2=CC(C(NCCCN3CCOCC3)=O)=NO2)C=C1. InChi Code: InChI=1S/C18H23N3O4/c1-23-15-5-3-14(4-6-15)17-13-16(20-25-17)18(22)19-7-2-8-21-9-11-24-12-10-21/h3-6,13H,2,7-12H2,1H3,(H,19,22). InChi Key:...
| Keywords: | 5-(4-methoxyphenyl)-N-[3-(4-morpholinyl)propyl]-3-isoxazolecarboxamide |
| Application: | Substituted isoxazole |
| CAS | 688050-45-5 |
| MW: | 345.4 D |
From 91.00€
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Shearinine B
Item number: Cay45476-1
Shearinine B is an indole diterpene originally isolated from E. shearii that has antiinsectan activity. Shearinine B (100 ppm in the diet) reduces the growth rate of H. zea larvae and the feeding rate of C. hemipterus larvae by 94 and 50%, respectively. It also induces 84% mortality in S. frugiperda larvae in a leaf...
| Keywords: | (2R,4bS,6aS,9aS,15bS,15cR,17aS)-5,6,6a,7,9,9a,10,12,15,15b,15c,16,17,17a-tetradecahydro-4b-hydroxy-2-(1-hydroxy-1-methylet... |
| Application: | Indole diterpene, antiinsectan agent |
| CAS | 163136-25-2 |
| MW: | 585.78 D |
From 235.00€
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Progabide
Item number: Cay45568-10
Progabide is a GABA receptor agonist. It selectively binds to the GABAA and GABAB receptors in postmortem rat cortical membranes (IC50s = 35 and 100 µM, respectively) over alpha- and beta-adrenergic, dopamine, serotonin, histamine H1, and muscarinic receptors (IC50s = >100 µM) in radioligand binding assays....
| Keywords: | SL 76002, 4-[[(4-chlorophenyl)(5-fluoro-2-hydroxyphenyl)methylene]amino]-butanamide |
| Application: | GABA receptor agonist |
| CAS | 62666-20-0 |
| MW: | 334.78 D |
From 64.00€
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Dabuzalgron (hydrochloride)
Item number: Cay45580-10
Dabuzalgron is a partial agonist of the alpha1A-adrenergic receptor (alpha1A-AR). It selectively binds to alpha1A-ARs over alpha1B- and alpha1D-ARs in CHO-K1 cells expressing the recombinant human receptors (Kis = 0.041, 1.6, and 6.5 µM, respectively) and selectively induces inositol phosphate accumulation in...
| Keywords: | Ro 115-1240, N-[6-chloro-3-[(4,5-dihydro-1H-imidazol-2-yl)methoxy]-2-methylphenyl]-methanesulfonamide, monohydrochloride |
| Application: | Alpha1A-AR partial agonist |
| CAS | 219311-43-0 |
| MW: | 354.25 D |
From 208.00€
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HC-5404
Item number: Cay45588-1
HC-5404 is an inhibitor of protein kinase R-like ER kinase (PERK, IC50 = 4 nM in a cell-free assay). It is selective for PERK over a panel of 25 kinases at 1 mM. HC-5404 reduces the levels of phosphorylated eukaryotic translation initiation factor 2alpha subunit (eIF2alpha) in HEK293 cells (IC50 = 33 nM). It reduces...
| Keywords: | LY-4,... |
| Application: | PERK (EIF2AK3) inhibitor |
| CAS | 2247396-91-2 |
| MW: | 454.48 D |
From 69.00€
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E3 Ligase Ligand 18
Item number: Cay45600-10
E3 ligase ligand 18 is a substituted purine derivative.. SMILES: NC(NC1=C2N=C(N1CC3=CC=C(Cl)C=C3)SC[C@H](NC(C)=O)C(O)=O)=NC2=O. InChi Code: InChI=1S/C17H17ClN6O4S/c1-8(25)20-11(15(27)28)7-29-17-21-12-13(22-16(19)23-14(12)26)24(17)6-9-2-4-10(18)5-3-9/h2-5,11H,6-7H2,1H3,(H,20,25)(H,27,28)(H3,19,22,23,26)/t11-/m0/s1....
| Keywords: | N-acetyl-S-[2-amino-9-[(4-chlorophenyl)methyl]-6,9-dihydro-6-oxo-1H-purin-8-yl]-L-cysteine |
| Application: | Substituted purine derivative |
| CAS | 2241669-88-3 |
| MW: | 436.87 D |
From 139.00€
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SKLB03220
Item number: Cay45614-1
SKLB03220 is a covalent inhibitor of the histone-lysine methyltransferase enhancer of zeste homolog 2 (EZH2, IC50 = 1.72 nM). It also inhibits EZH2A677G, EZH2Y641N, and EZH2Y641F, mutations found in various cancers, when used at a concentration of 10 nM. SKLB03220 is selective for EZH2 over a variety of other...
| Keywords: | N-[(1,2-dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl]-5-[ethyl(tetrahydro-2H-pyran-4-yl)amino]-2',4-dimethyl-5'-[(1-oxo-2... |
| Application: | Covalent EZH2 inhibitor |
| CAS | 2852050-29-2 |
| MW: | 556.71 D |
From 35.00€
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