ARN3261

ARN3261 is an inhibitor of salt-inducible kinase 2 (SIK2). It induces apoptosis in OVCAR-8, SKOV3, and OC 316 ovarian cancer cells and inhibits growth in ten ovarian cancer cell lines (IC50s = 0.8-2.6 µM). ARN3261 enhances sensitivity to carboplatin (Cay13112) in both carboplatin-sensitive and -resistant ovarian cancer cells and increases carboplatin-induced DNA damage and apoptosis in OVCAR-8, SKOV3, and OC 316 cells. It reduces tumor weight in a SKOV3 mouse xenograft model when administered at a dose of 40 mg/kg with carboplatin.. SMILES: O=S(N1CCC(CC1)N2N=CC(C3=CN=C4NC=C(C5=CC(F)=CC(F)=C5OC)C4=C3)=C2)(C)=O. InChi Code: InChI=1S/C23H23F2N5O3S/c1-33-22-18(8-16(24)9-21(22)25)20-12-27-23-19(20)7-14(10-26-23)15-11-28-30(13-15)17-3-5-29(6-4-17)34(2,31)32/h7-13,17H,3-6H2,1-2H3,(H,26,27). InChi Key: NIFLRVAYOHHDFN-UHFFFAOYSA-N