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Rezvilutamide
Item number: Cay45332-10
Rezvilutamide is a non-steroidal androgen receptor antagonist. It reduces secretion of prostate-specific androgen (PSA) from LNCaP prostate cancer cells (IC50 = 22 nM) and reduces proliferation of the same cells (IC50 = 33 nM). Formulations containing rezvilutamide have been used in the treatment of prostate...
| Keywords: | SHR-3680,... |
| Application: | Non-steroidal androgen receptor antagonist |
| CAS | 1572045-62-5 |
| MW: | 479.47 D |
From 271.00€
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Pincainide
Item number: Cay45339-1
Pincainide is a calcium channel inhibitor. It reduces norepinephrine-induced calcium influx and increases calcium efflux in isolated rat aortic strips. Pincainide reduces phasic and tonic contractions induced by norepinephrine (IC50s = 880 and 780 µM, respectively) and high potassium (IC50s = 620 and 670 µM,...
| Keywords: | IQB-M-81, N-(2,6-dimethylphenyl)hexahydro-1H-azepine-1-acetamide |
| Application: | Calcium channel inhibitor |
| CAS | 83471-41-4 |
| MW: | 260.38 D |
From 139.00€
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UC-112
Item number: Cay45378-10
UC-112 is a Smac mimetic. It reduces the level of survivin and induces apoptosis in A375 melanoma and PC3 prostate cancer cells and inhibits the growth of A375, M14 human melanoma, PC3 and DU145 prostate cancer cells (IC50s = 1.6, 2.5, 0.7, and 3.4 µM, respectively). In vivo, UC-112 (20 and 40 mg/kg) reduces tumor...
| Keywords: | 5-[(phenylmethoxy)methyl]-7-(1-pyrrolidinylmethyl)-8-quinolinol |
| Application: | Smac mimetic |
| CAS | 383392-66-3 |
| MW: | 348.45 D |
From 189.00€
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hGPR91 Antagonist 3
Item number: Cay45388-1
hGPR91 antagonist 3 is an antagonist of succinate receptor 1, also known as G protein-coupled receptor 91 (GPR91, IC50 = 35 nM).. SMILES: FC(F)(C(C=C(C1=NOC(CNC(CCCC2=CC=C(C=CC=N3)C3=N2)=O)=C1)C=C4)=C4F)F. InChi Code:...
| Keywords: | Human G Protein-coupled Receptor 91 Antagonist 3, Human GPR91 Antagonist 3, Succinate Receptor 1 Antagonist 3, SUCNR1... |
| Application: | Succinate receptor 1 (GPR91) antagonist |
| CAS | 1314796-31-0 |
| MW: | 458.42 D |
From 110.00€
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M435-1279
Item number: Cay45401-1
M435-1279 is an inhibitor of ubiquitin-conjugating enzyme E2T (UBE2T). It binds to UBE2T (Kd = 50.5 µM), inhibits UBE2T-mediated degradation of receptor for activated C kinase 1 (RACK1), and reduces hyperactive Wnt/beta-catenin signaling. M435-1279 reduces the viability of MKN45 and AGS gastric cancer cells when...
| Keywords: | N-[4-(aminosulfonyl)phenyl]-1,2,5,6,7,8-hexahydro-4-hydroxy-2-oxo-[1]benzothieno[2,3-b]pyridine-3-carboxamide |
| Application: | UBE2T inhibitor |
| CAS | 1359431-16-5 |
| MW: | 419.47 D |
From 69.00€
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TSPO Ligand-1
Item number: Cay45402-10
TSPO ligand-1 is an intermediate in the synthesis of 2-phenylindolglyoxylamide derivatives that bind translocator protein, formerly known as translocator protein (18 kDa) (TSPO). It has been used in the synthesis of fluorescent probes that are selective for translocator protein. TSPO ligand-1 has also been used in...
| Keywords: | Translocator Protein Ligand-1, alpha-oxo-2-phenyl-1H-indole-3-acetyl chloride |
| Application: | 2-phenylindolglyoxylamide derivative intermediate, TSPO binding |
| CAS | 4560-08-1 |
| MW: | 283.71 D |
From 64.00€
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Proquazone
Item number: Cay45454-1
Proquazone is a non-steroidal anti-inflammatory drug (NSAID). It reduces carrageenan-induced edema in rats (ED50 = 5 mg/kg, p.o.) and bradykinin-induced bronchoconstriction in guinea pigs (ED50 = 0.01 mg/kg, i.v.). It also inhibits yeast-induced pyresis in rats. Formulations containing proquazone have been used in...
| Keywords: | RU 43-715, Sandoz-43-715, 7-methyl-1-(1-methylethyl)-4-phenyl-2(1H)-quinazolinone |
| Application: | NSAID |
| CAS | 22760-18-5 |
| MW: | 278.36 D |
From 140.00€
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Tracazolate
Item number: Cay45457-1
Tracazolate is a positive allosteric modulator of the GABAA receptor (GABAAR). It potentiates GABA-stimulated currents in X. laevis oocytes expressing alpha1beta3gamma2s and alpha1beta1delta subunit-containing GABAARs (EC50s = 1.5 and 16.7 µM, respectively) and increases the maximal response to GABA in X. laevis...
| Keywords: | ICI 136753, 4-(butylamino)-1-ethyl-6-methyl-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid, ethyl ester |
| Application: | GABAA receptor positive allosteric modulator |
| CAS | 41094-88-6 |
| MW: | 304.39 D |
From 139.00€
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VEGFR2 Kinase Inhibitor IV
Item number: Cay45474-1
VEGFR2 kinase inhibitor IV is an inhibitor of VEGFR2 (IC50 = 19 nM). It is greater than 100-fold selective for VEGFR2 over FGFR1 and Src but only 1.8-, 10-, and 10-fold selective over PDGFRbeta, FLT1, and FLT2, respectively. VEGFR2 kinase inhibitor IV inhibits mitogenesis in human umbilical vein endothelial cells...
| Keywords: | Vascular Endothelial Growth Factor Receptor 2 Kinase Inhibitor IV,... |
| Application: | VEGFR2 inhibitor |
| CAS | 216661-57-3 |
| MW: | 307.37 D |
From 278.00€
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YIC-C8-434
Item number: Cay45487-1
YIC-C8-434 is an inhibitor of acyl-CoA:cholesterol acyltransferase (ACAT, IC50 = 11 nM in isolated rat hepatic microsomes). It reduces plasma cholesterol levels by 79% in rats when administered at a dose of 0.005% in a high-cholesterol diet. Oral administration of YIC-C8-434 (8.3 mg/kg per day) reduces cholesterol...
| Keywords: | (2E)-3-[3,5-dimethoxy-4-(octyloxy)phenyl]-1-[4-(3,4-dimethylphenyl)-1-piperazinyl]-2-propen-1-one |
| Application: | ACAT inhibitor |
| CAS | 214265-97-1 |
| MW: | 508.7 D |
From 91.00€
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2-Aminoterephthalic Acid
Item number: Cay45551-10
2-Aminoterephthalic acid is a building block that has been used as a ligand in coordination chemistry and in the synthesis of metal-organic frameworks (MOFs). SMILES: NC1=CC(C(O)=O)=CC=C1C(O)=O. InChi Code: InChI=1S/C8H7NO4/c9-6-3-4(7(10)11)1-2-5(6)8(12)13/h1-3H,9H2,(H,10,11)(H,12,13). InChi Key:...
| Keywords: | 2-ATA, 2-amino-1,4-benzenedicarboxylic acid |
| Application: | Building block |
| CAS | 10312-55-7 |
| MW: | 181.15 D |
From 35.00€
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NO-Pravastatin
Item number: Cay10006044-1
NO-pravastatin is a derivative of pravastatin (Cay10010343) that contains a nitric oxide-releasing moiety. It induces cGMP formation in PC12 cells (EC50 = 2.3 µM) and inhibits the proliferation of isolated rat aortic smooth muscle cells (IC50 = 2.2 µM). NO-pravastatin reduces inducible nitric oxide synthase (iNOS)...
| Keywords: | NCX 6550,... |
| Application: | Nitric oxide-releasing moiety containing pravastatin derivative, HMG-CoA reductase inhibitor |
| CAS | 733034-46-3 |
| MW: | 541.64 D |
From 35.00€
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