YIC-C8-434

YIC-C8-434 is an inhibitor of acyl-CoA:cholesterol acyltransferase (ACAT, IC50 = 11 nM in isolated rat hepatic microsomes). It reduces plasma cholesterol levels by 79% in rats when administered at a dose of 0.005% in a high-cholesterol diet. Oral administration of YIC-C8-434 (8.3 mg/kg per day) reduces cholesterol absorption by the small intestine by 17% in rats. YIC-C8-434 is primarily metabolized by the cytochrome P450 (CYP) isoform CYP3A2, which is expressed at lower levels in the female rat liver, and is selectively toxic to female rats, where it reduces food intake, weight gain, and organ weights.. SMILES: CCCCCCCCOC1=C(C=C(C=C1OC)/C=C/C(N2CCN(C3=CC(C)=C(C=C3)C)CC2)=O)OC. InChi Code: InChI=1S/C31H44N2O4/c1-6-7-8-9-10-11-20-37-31-28(35-4)22-26(23-29(31)36-5)13-15-30(34)33-18-16-32(17-19-33)27-14-12-24(2)25(3)21-27/h12-15,21-23H,6-11,16-20H2,1-5H3/b15-13+. InChi Key: YGEPYVAQKIHLFY-FYWRMAATSA-N