Proquazone

Proquazone is a non-steroidal anti-inflammatory drug (NSAID). It reduces carrageenan-induced edema in rats (ED50 = 5 mg/kg, p.o.) and bradykinin-induced bronchoconstriction in guinea pigs (ED50 = 0.01 mg/kg, i.v.). It also inhibits yeast-induced pyresis in rats. Formulations containing proquazone have been used in the treatment of rheumatoid arthritis, osteoarthritis, and ankylosing spondylitis.. SMILES: CC1=CC(N2C(C)C)=C(C(C3=CC=CC=C3)=NC2=O)C=C1. InChi Code: InChI=1S/C18H18N2O/c1-12(2)20-16-11-13(3)9-10-15(16)17(19-18(20)21)14-7-5-4-6-8-14/h4-12H,1-3H3. InChi Key: JTIGKVIOEQASGT-UHFFFAOYSA-N