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GSK180
Item number: Cay19217-1
An inhibitor of kynurenine 3-monooxygenase (IC50 = 6.3 nM), selective for human over P. fluorescens kynurenine 3-monooxygenase (IC50 = 500 nM), increases circulating levels of kynurenine and kynurenic acid in mice at 27 mg/kg, protects against secondary acute lung injury and renal injury in a rat model of...
| Keywords: | 5,6-dichloro-2-oxo-3(2H)-benzoxazolepropanoic acid |
| Application: | Kynurenine 3-monooxygenase inhibitor |
| CAS | 1799725-26-0 |
| MW: | 276.1 D |
From 55.00€
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WAY-181187
Item number: Cay23461-10
A 5-HT6 receptor agonist, increases intracellular cAMP levels in HeLa cells expressing 5-HT6 (EC50 = 6.5 nM), selectively binds to 5-HT6 over 5-HT2B, 5-HT2C, and 5-HT7 (Kis = 2,458, 124, and 679 nM, respectively), selective for 5-HT6 over a panel of 31 receptors and ion channels at 100 nM, increases extracellular...
| Keywords: | SAX 187, 1-[(6-chloroimidazo[2,1-b]thiazol-5-yl)sulfonyl]-1H-indole-3-ethanamine |
| Application: | 5-HT6 receptor agonist |
| CAS | 554403-49-5 |
| MW: | 380.87 D |
From 105.00€
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Navoximod
Item number: Cay28440-1
An IDO1 inhibitor (IC50 = 28 nM for the recombinant human enzyme), decreases tumor volume in a Panc02 murine PDAC model at 500 mg/kg. Formulation: A solid. InChI: InChI=1S/C18H21FN2O2/c19-14-3-1-2-13-16-9-20-10-21(16)15(18(13)14)8-17(23)11-4-6-12(22)7-5-11/h1-3,9-12,15,17,22-23H,4-8H2/t11-,12-,15-,17+/m0/s1....
| Keywords: | GDC-0919, NLG-919, RG6078, (aR,5S)-6-fluoro-a-(trans-4-hydroxycyclohexyl)-5H-imidazo[5,1-a]isoindole-5-ethanol |
| Application: | IDO1 inhibitor |
| CAS | 1402837-78-8 |
| MW: | 316.4 D |
From 239.00€
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TC 13172
Item number: Cay31034-1
An inhibitor of MLKL and necroptosis, selective for MLKL over RIPK1 and RIPK3 at 10 µM, inhibits TSZ-induced necroptosis in HT-29 cells (EC50 = 2 nM), inhibits TSZ-induced oligomerization of MLKL and translocation of MLKL to the plasma membrane in HT-29 cells at 100 nM. Formulation: A solid. InChI:...
| Keywords: | 3,7-dihydro-3-[3-(3-hydroxyphenyl)-2-propyn-1-yl]-1,7-dimethyl-8-(methylsulfonyl)-1H-purine-2,6-dione |
| Application: | MLKL / necroptosis inhibitor |
| CAS | 2093393-05-4 |
| MW: | 388.4 D |
From 76.00€
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GLPG1205
Item number: Cay33185-1
A GPR84 antagonist, inhibits DIM-induced GTPgammaS binding in cells overexpressing human GPR84 (IC50 = 54 nM), inhibits embelin-induced chemotaxis of isolated human neutrophils (IC50 = 11 nM), reduces body weight loss and rectal bleeding and improves stool consistency in a rat model of DSS-induced colitis....
| Keywords: | 9-(2-cyclopropylethynyl)-2-[(2S)-1,4-dioxan-2-ylmethoxy]-6,7-dihydro-4H-pyrimido[6,1-a]isoquinolin-4-one |
| Application: | GPR84 antagonist |
| CAS | 1445847-37-9 |
| MW: | 378.4 D |
From 101.00€
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Deferitazole
Item number: Cay33329-1
An iron chelator, decreases the levels of iron in iron-citrate complexes at 50 µM, reduces the number of P. falciparum oocytes, an effect that can be prevented by the addition of ferric chloride, and the percent of flagellated P. falciparum male gametocytes in vitro at 25 µM, decreases the urine and fecal levels of...
| Keywords: | FBS0701, SPD-602, 4S,5-dihydro-2-[2-hydroxy-3-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]phenyl]-4-methyl-4-thiazolecarboxylic acid |
| Application: | Iron chelator |
| CAS | 945635-15-4 |
| MW: | 399.46 D |
From 122.00€
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EN4
Item number: Cay33473-10
A covalent inhibitor of c-Myc, inhibits c-Myc-induced increases in transcriptional activity in a reporter assay using HEK293T cells (EC50 = 12.5 µM), reduces the proliferation of 231MFP cells at 50 µM, decreases tumor volume in a 231MFP mouse xenograft model at 50 mg/kg per day. Formulation: A solid. InChI:...
| Keywords: | N-[2-(4-ethoxyphenoxy)phenyl]-4-[[(1-oxo-2-propen-1-yl)amino]methyl]-benzamide |
| Application: | Covalent c-Myc inhibitor |
| CAS | 1197824-15-9 |
| MW: | 416.47 D |
From 101.00€
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Erinacine B
Item number: Cay40078-250
A cyathin diterpenoid, induces NGF secretion in isolated mouse astroglial cells at 1 mM. Formulation: A solution in acetonitrile. InChI:...
| Keywords: | (-)-Erinacine B, Erinacin B,... |
| Application: | Cyathin diterpenoid, fungal metabolite |
| CAS | 156101-10-9 |
| MW: | 432.6 D |
535.00€
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Perfluorohexyloctane
Item number: Cay40490-1
A semifluorinated alkane and PFAS, improves corneal penetration of cyclosporine A in porcine eyes ex vivo at 0.05 and 0.1%, topical application improves the lipid layer grade in rabbit eyes in vivo without inducing irritation. Formulation: A solid. InChI:...
| Keywords: | 1-(Perfluorohexyl)octane, F6H8, NOV03, 1,1,1,2,2,3,3,4,4,5,5,6,6-tridecafluoro-tetradecane |
| Application: | Semifluorinated alkane, PFAS |
| CAS | 133331-77-8 |
| MW: | 432.26 D |
376.00€
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BSJ-04-132
Item number: Cay41248-1
A PROTAC that drives Cdk4 degradation, selectively induces the degradation of Cdk4 over Cdk6, IKZF1, and IKZF3 in a cereblon-dependent manner in Jurkat cells at 1 µM. Formulation: A solid. InChI:...
| Keywords: | 7-cyclopentyl-2-[[5-[4-[4-[[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]acetyl]amino]butyl]... |
| Application: | Cdk4 degradation driving PROTAC |
| CAS | 2349356392 |
| MW: | 819.9 D |
From 178.00€
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E17241
Item number: Cay41675-1
An inducer of ABCA1 expression, induces the expression of ABCA1 in a reporter assay using HepG2 cells (EC50 = 280 nM), an agonist of PPARs, induces PPAR-mediated gene expression in reporter assays using HepG2 cells expressing PPARgamma, PPARalpha, or PPARdelta (EC50s = 290, 3,900, and 879 nM, respectively),...
| Keywords: | 4-(1,3-Dithiolan-2-yl)-N-(3-hydroxypyridin-2-yl)benzamide, 4-(1,3-dithiolan-2-yl)-N-(3-hydroxypyridin-2-yl)benzamide |
| Application: | ABCA1 expression inducer |
| CAS | 1060968-92-4 |
| MW: | 318.4 D |
From 70.00€
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Werner Syndrome RecQ Helicase-IN-2
Item number: Cay41678-1
An inhibitor of WRN (IC50 = 100 nM), selectively inhibits the growth of SW48 cells over DLD-1-WRN-KO cells (GI50s = 100 and >10,000 nM, respectively), reduces tumor volume in an SW48 mouse xenograft model at 120 mg/kg per day. Formulation: A solid. InChI:...
| Keywords: | Werner Syndrome RecQ Helicase Inhibitor 2, WS RecQ Helicase Inhibitor 2, WS RecQ Helicase-IN-2,... |
| Application: | WRN inhibitor |
| CAS | 2869954-51-6 |
| MW: | 681.7 D |
From 153.00€
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