8-chloro Caffeine

8-chloro Caffeine is a derivative of the methylxanthine alkaloid caffeine (Cay-14118). It binds to adenosine receptors (apparent Ki = 30 µM). 8-chloro Caffeine (250 µM) potentiates UV-induced chromosomal aberrations in Cl-I Chinese hamster embryonic lung cells. It has also been used in the synthesis of mixed lineage kinase domain-like protein (MLKL) inhibitors with necroptosis-inhibiting activity.Formal Name: 8-chloro-3,7-dihydro-1,3,7-trimethyl-1H-purine-2,6-dione. CAS Number: 4921-49-7. Synonyms: NSC 6277. Molecular Formula: C8H9ClN4O2. Formula Weight: 228.6. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: Chloroform: soluble. lambdamax: 277 nm. SMILES: O=C1C2=C(N(C)C(N1C)=O)N=C(N2C)Cl. InChi Code: InChI=1S/C8H9ClN4O2/c1-11-4-5(10-7(11)9)12(2)8(15)13(3)6(4)14/h1-3H3. InChi Key: HGKPGBJNNATDRR-UHFFFAOYSA-N.