666-15

666-15 is an inhibitor of gene transcription mediated by cAMP-response-element-binding protein (CREB, IC50 = 81 nM in a cell-based reporter assay). It inhibits the growth of A549, MCF-7, MDA-MB-231, and MDA-MB-468 cells (GI50s = 0.47, 0.31, 0.073, and 0.046 µM, respectively). 666-15 (10 mg/kg per day, five days per week) reduces tumor growth in an MDA-MB-468 mouse xenograft model.Formal Name: 3-(3-aminopropoxy)-N-[2-[[3-[[(4-chloro-2-hydroxyphenyl)amino]carbonyl]-2-naphthalenyl]oxy]ethyl]-2-naphthalenecarboxamide, monohydrochloride. CAS Number: 1433286-70-4. Synonyms: Compound 3i. Molecular Formula: C33H30ClN3O5 . HCl. Formula Weight: 620.5. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 5mg/mL, DMSO: 5mg/mL. lambdamax: 236 nm. SMILES: O=C(NCCOC1=CC(C=CC=C2)=C2C=C1C(NC3=C(O)C=C(Cl)C=C3)=O)C4=CC(C=CC=C5)=C5C=C4OCCCN.Cl. InChi Code: InChI=1S/C33H30ClN3O5.ClH/c34-25-10-11-28(29(38)20-25)37-33(40)27-17-22-7-2-4-9-24(22)19-31(27)42-15-13-36-32(39)26-16-21-6-1-3-8-23(21)18-30(26)41-14-5-12-35,/h1-4,6-11,16-20,38H,5,12-15,35H2,(H,36,39)(H,37,40),1H. InChi Key: LELLCPHHYHLWBH-UHFFFAOYSA-N.