5-Octyl-alpha-ketoglutarate

In addition to its role in the Krebs cycle, alpha-ketoglutarate (2-oxoglutarate) has roles as a substrate or modulator of enzymes. 5-Octyl-alpha-ketoglutarate, also known as alpha-ketoglutarate octyl ester, is a stable, cell-permeable molecule that generates free alpha-ketoglutarate upon hydrolysis of the ester bond by cytoplasmic esterases. It is used in experiments to increase levels of intracellular alpha-ketoglutarate. 5-Octyl-alpha-ketoglutarate has been shown to modulate a variety of enzymes and signaling pathways, particularly in the context of glycolysis, hypoxia, and cancer.Formal Name: 2-oxo-pentanedioic acid, 5-octyl ester. CAS Number: 1616344-00-3. Synonyms: alpha-KG octyl ester. Molecular Formula: C13H22O5. Formula Weight: 258.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 10 mg/ml, DMSO: 10 mg/ml, Ethanol: 20 mg/ml, PBS (pH 7.2): 1 mg/ml. SMILES: CCCCCCCCOC(CCC(C(O)=O)=O)=O. InChi Code: InChI=1S/C13H22O5/c1-2-3-4-5-6-7-10-18-12(15)9-8-11(14)13(16)17/h2-10H2,1H3,(H,16,17). InChi Key: SZEOIQZPNSBRJC-UHFFFAOYSA-N.