5-Bromouridine

5-Bromouridine is a brominated analog of the nucleoside uridine (Cay-20300). It can be incorporated into RNA and subsequently detected by antibodies against bromodeoxyuridine (Cay-15580). 5-Bromouridine decreases the viability of HL-60 and MOLT-4 cells (LC50s = 10 and 20 µM, respectively). It induces apoptosis and halts the cell cycle at the S phase in HL-60 cells. It is photoreactive, and UV irradiation has been used to cross-link RNA containing 5-bromouridine to proteins in the study of of RNA-protein interactions. 5-Bromouridine can also be incorporated into RNA using 5-bromouridine 5'-triphosphate (Cay-18140).Formal Name: 5-bromo-uridine. CAS Number: 957-75-5. Synonyms: (-)-5-Bromouridine, BrU, BrUrd, NSC 38296. Molecular Formula: C9H11BrN2O6. Formula Weight: 323.1. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 10mg/mL, DMSO: 15mg/mL, PBS (pH 7.2): 5mg/mL. lambdamax: 211, 280 nm. SMILES: O=C1N([C@]2([H])O[C@H](CO)[C@@H](O)[C@H]2O)C=C(Br)C(N1)=O. InChi Code: InChI=1S/C9H11BrN2O6/c10-3-1-12(9(17)11-7(3)16)8-6(15)5(14)4(2-13)18-8/h1,4-6,8,13-15H,2H2,(H,11,16,17)/t4-,5-,6-,8-/m1/s1. InChi Key: AGFIRQJZCNVMCW-UAKXSSHOSA-N.