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Local catabolism of the amino acid tryptophan by indoleamine 2,3-dioxygenase (IDO) is considered an important mechanism of regulating T-cell immunity. Inhibition of the production of T helper-1 (TH1) cytokines offers a new strategy for treating TH1 mediated autoimmune diseases such as multiple sclerosis. 3,4-DAA is an orally active synthetic derivative of the tryptophan metabolite anthranilic acid. It suppresses antigen-specific proliferation of MBP Ac1-11 TCR CD4+ T-cells. At a concentration of 200 µM, 3,4-DAA reduces IFN-gamma, IL-2, IL-12/23 p40, and TNFalpha in splenocytes from antigen-induced transgenic mice. However, at a concentration of 30 µM, IL-4, and IL-10 levels were increased. Expression of inducible nitric oxide synthase and nitric oxide release from EOC20 cells induced by IFN-gamma and LPS are also suppressed by 3,4-DAA at concentration of 30-200 µM. Mice with experimental autoimmune encephalomyelitis treated orally (300 mg/kg per day) with 3,4-DAA exhibited fewer and milder relapses and less severe disease compared to control animals.Formal Name: 2-[3-(3,4-dimethoxy-phenyl)-acryloylamino]-3-hydroxy-benzoic acid. CAS Number: 2117759-07-4. Molecular Formula: C18H17NO6. Formula Weight: 343.3. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMF:PBS (pH 7.2) (1:1): .5 mg/ml, DMSO: 20 mg/ml, Ethanol: 1 mg/ml. lambdamax: 347 nm. SMILES: COc1ccc(\C=C/C(=O)Nc2c(O)cccc2C(=O)O)cc1OC. InChi Code: InChI=1S/C18H17NO6/c1-24-14-8-6-11(10-15(14)25-2)7-9-16(21)19-17-12(18(22)23)4-3-5-13(17)20/h3-10,20H,1-2H3,(H,19,21)(H,22,23)/b9-7+. InChi Key: HUBVPPBIEOCMIE-VQHVLOKHSA-N.
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