2',3'-cGAMP-iFluor 488 conjugate

Correction Factor (260 nm): 0.21 Correction Factor (280 nm): 0.11 Extinction coefficient (cm^-1 M^-1): 75000 (aqueous buffer (pH 7.2)) Excitation (nm): 491 Emission (nm): 516 Quantum yield: 0.9 (aqueous buffer (pH 7.2)). iFluor(R) 488-labeled cGAMP provides an excellent fluorescent probe for developing fluorescence-based assays and tests for detecting cGAMP or monitoring its activity. iFluor(R) 488 conjugates are significantly brighter than fluorescein conjugates and are much more photostable. Additionally, the fluorescence of iFluor(R) 488 is not affected by pH (4-10). 2',3'-cGAMP has gained significant attention in recent years due to its potential as a therapeutic target for diseases such as cancer and viral infections. It has been shown to activate the immune system and enhance the efficacy of immune checkpoint inhibitors, which are a type of cancer immunotherapy. 2',3'-cGAMP (cyclic GMP-AMP) is a cyclic dinucleotide second messenger molecule that plays a critical role in the innate immune system. It is synthesized by the enzyme cGAS (cyclic GMP-AMP synthase) in response to cytosolic DNA that has been released from damaged or infected cells. Once synthesized, 2',3'-cGAMP binds to the adaptor protein STING (stimulator of interferon genes) and triggers downstream signaling pathways that result in the production of type I interferons and other cytokines, leading to an immune response against the invading pathogen.