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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
ABD-20330 | 100 µg | - |
3 - 8 business days* |
1,186.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
DBCO (dibenzocyclooctyne) click chemistry is a bioconjugation technique used to covalently attach... more
Product information "2',3'-cGAMP-DBCO conjugate"
DBCO (dibenzocyclooctyne) click chemistry is a bioconjugation technique used to covalently attach molecules to biological targets, such as proteins, peptides, and nucleic acids. It involves the reaction between DBCO-functionalized molecules and a complementary azide-functionalized molecule in the presence of a copper-free catalyst, forming a stable triazole linkage. 2',3'-cGAMP-DBCO conjugate is an excellent building block to develop 2',3'-cGAMP probes for investigating the biological activities and functions of 2',3'-cGAMP. 2',3'-cGAMP has gained significant attention in recent years due to its potential as a therapeutic target for diseases such as cancer and viral infections. It has been shown to activate the immune system and enhance the efficacy of immune checkpoint inhibitors, which are a type of cancer immunotherapy. 2',3'-cGAMP (cyclic GMP-AMP) is a cyclic dinucleotide second messenger molecule that plays a critical role in the innate immune system. It is synthesized by the enzyme cGAS (cyclic GMP-AMP synthase) in response to cytosolic DNA that has been released from damaged or infected cells. Once synthesized, 2',3'-cGAMP binds to the adaptor protein STING (stimulator of interferon genes) and triggers downstream signaling pathways that result in the production of type I interferons and other cytokines, leading to an immune response against the invading pathogen. Solvent: DMSO.
Supplier: | AAT Bioquest |
Supplier-Nr: | 20330 |
Properties
Application: | Click chemistry, 2',3'-cGAMP probe generation |
MW: | 1539.59 D |
Database Information
Handling & Safety
Storage: | -20°C (protect from light) |
Shipping: | +4°C (International: °C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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