(1S,3R)-RSL3

(1S,3R)-RSL3
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay19288-1 1 mg -

approx. 1-3 business days

32.00€
Cay19288-5 5 mg -

6 - 10 business days*

110.00€
Cay19288-10 10 mg -

6 - 10 business days*

204.00€
Cay19288-25 25 mg -

6 - 10 business days*

430.00€
 
(1S,3R)-RSL3 is an inhibitor of glutathione peroxidase 4 (GPX4) that induces a lethal... more
Product information "(1S,3R)-RSL3"
(1S,3R)-RSL3 is an inhibitor of glutathione peroxidase 4 (GPX4) that induces a lethal accumulation of lipid hydroperoxides and ferroptotic cell death (EC50 = 0.01 µM in HRASV12-expressing BJeHLT cells). It is selective for HRASV12-expressing over wild-type BJeHLT cells (EC50 = 2 µM). (1S,3R)-RSL3 reduces tumor volume in various mouse xenograft models, with diffuse large B cell lymphomas and renal cell carcinomas being most sensitive. Formal Name: (1S,3R)-2-(2-chloroacetyl)-2,3,4,9-tetrahydro-1-[4-(methoxycarbonyl)phenyl]-1H-pyrido[3,4-b]indole-3-carboxylic acid, methyl ester. CAS Number: 1219810-16-8. Molecular Formula: C23H21ClN2O5. Formula Weight: 440.9. Purity: >98%. Formulation: A crystalline solid. Solubility: DMF: 30 mg/mL, DMSO: 30 mg/mL, DMSO:PBS (pH 7.2) (1:2): 0.33 mg/mL, Ethanol: 25 mg/mL. lambdamax: 220 nm. SMILES: O=C(OC)[C@@H]1N(C(CCl)=O)[C@@H](C2=CC=C(C(OC)=O)C=C2)C3=C(C(C=CC=C4)=C4N3)C1. InChi Code: InChI=1S/C23H21ClN2O5/c1-30-22(28)14-9-7-13(8-10-14)21-20-16(15-5-3-4-6-17(15)25-20)11-18(23(29)31-2)26(21)19(27)12-24/h3-10,18,21,25H,11-12H2,1-2H3/t18-,21+/m1/s1. InChi Key: TXJZRSRTYPUYRW-NQIIRXRSSA-N.
Keywords: (1S,3R)-2-(2-chloroacetyl)-2,3,4,9-tetrahydro-1-[4-(methoxycarbonyl)phenyl]-1H-pyrido[3,4-b]indole-3-carboxylic acid, methyl ester
Supplier: Cayman Chemical
Supplier-Nr: 19288

Properties

Application: GPX4 inhibitor
MW: 440.9 D
Formula: C23H21ClN2O5
Purity: >98%
Format: Crystalline Solid

Database Information

CAS : 1219810-16-8| Find alternatives
KEGG ID : K05361 | Find alternatives

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Signal Word: Warning
GHS Hazard Pictograms:
H Phrases: H302, H400, H410
P Phrases: P264, P270, P273, P301+310, P330, P391, P501
Caution
Our products are for laboratory research use only: Not for administration to humans!
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