98 products were found matching "K05361"!

(1S,3R)-RSL3 is a ferroptosis inducer and is canonically known as an inhibitor of glutathione peroxidase 4 (GPX4). It inhibits GPX4 in a context-dependent manner: (1S,3R)-RSL3 inhibits GPX4 in the presence of cell cytosol or recombinant human 14-3-3epsilon, an adaptor protein, but does not inhibit recombinant human...

DEL-I25 is an activator of glutathione peroxidase 4 (GPX4) containing the loss-of-function mutation R152H (GPX4R152H). It selectively binds to GPX4R152H over wild-type GPX4 (Kds = 2 and 110 µM, respectively). DEL-I25 increases the viability of fibroblasts expressing GPX4R152H isolated from patients with...

Altretamine-d18 is intended for use as an internal standard for the quantification of altretamine (Cay-23662) by GC- or LC-MS. Altretamine is an anticancer agent. It induces cytotoxicity in an ovarian cancer cell line when used at a concentration of 10 µg/ml. Altretamine (0. mM) inhibits glutathione peroxidase 4...

The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of hydrogen peroxide, organic hydroperoxides and lipid hydroperoxides, and thereby protect cells against oxidative damage. Several isozymes of this gene family exist in vertebrates, which vary in...

The selenoprotein glutathione peroxidase 4 (GPX4) is a master regulator of ferroptosis, a form of programmed cell death induced by iron-dependent lipid peroxidation. GPX4 converts lipid hydroperoxides to non-toxic lipid alcohols, therefore preventing ferroptosis. Research studies show that selenium enhances GPX4...

Liproxstatin-1 is a ferroptosis inhibitor. It inhibits ferroptotic cell death (IC50 = 22 nM) and lipid peroxidation in mouse embryonic fibroblasts (MEFs) with an inducible knockdown of glutathione peroxidase 4 (Gpx4-/- MEFs) when used at a concentration of 50 nM. Liproxstatin-1 also inhibits ferroptosis induced by...

GPX4 (R)-9i is a ferroptosis inducer. It binds to GPX4 in a cellular thermal shift assay (CETSA) using HT-1080 fibrosarcoma cells (Kd = 20. nM) and inhibits GPX4 activity in a cell-free assay. It is cytotoxic to HT-1080 cells, an effect that can be reversed by the ferroptosis inhibitor ferrostatin-1 (IC50s = 0. and...

The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of hydrogen peroxide, organic hydroperoxides and lipid hydroperoxides, and thereby protect cells against oxidative damage. Several isozymes of this gene family exist in vertebrates, which vary in...

FIN56 is an inducer of ferroptosis and a derivative of CIL56 (Cay-19287). It selectively induces ferroptosis in BJ cells overexpressing oncogenic HRASG12V via acetyl-CoA carboxylase-dependent reduction in expression of GPX4 protein. This effect is reversed by the ferroptosis inhibitors deferoxamine (Cay-14595) and...

A covalent GPX4 inhibitor (IC50 = 130 nM), inhibits the growth of MDA-MB-468, BT-549, and MDA-MB-231 cells (IC50s = 12, 3.4, and 8 nM, respectively), increases lipid peroxidation and MDA levels in MDA-MB-231 cells at 10 and 20 µM, decreases mitochondrial volume and induces degradation of mitochondrial crests and...

FINO2 is a ferroptosis-inducing peroxide compound that indirectly inhibits glutathione peroxidase 4 (GPX4) and oxidizes iron. It decreases GPX4 activity and protein levels in vitro but does not act as an active site, allosteric, or covalent inhibitor of GPX4 or alter GPX homeostasis. It also oxidizes iron in vitro,...

GPX4 activator 2 is a ligand for glutathione peroxidase 4 (GPX4, Kd = 0. µM). It inhibits erastin-induced ferroptosis in HT-1080 fibrosarcoma cells (EC50 = 7. µM). GPX4 activator 2 (10 µM) prevents erastin-induced increases in lipid peroxide levels in HT-1080 cells. In vivo, GPX4 activator 2 (25 mg/kg) decreases...