- Search results for K05361
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52 products were found matching "K05361"!
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Item number: Cay39919-25
N6F11 is an inducer of ferroptosis. It increases the thermal stability of the ubiquitin ligase TRIM25 in a cellular thermal shift assay (CETSA) using PANC-1 pancreatic cancer cells when used at a concentration of 10 µM and enhances TRIM25-dependent ubiquitination of glutathione peroxidase 4 (GPX4) in a cell-free...
Keywords: | 2-(chloromethyl)-6-(4-chlorophenyl)-thieno[3,2-d]pyrimidin-4(3H)-one |
Application: | Ferroptosis inducer, GPX4 degradation inducer |
CAS | 851398-76-0 |
MW: | 313.2 D |
From 47.00€
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Item number: Cay19288-5
(1S,3R)-RSL3 is a ferroptosis inducer and is canonically known as an inhibitor of glutathione peroxidase 4 (GPX4). It inhibits GPX4 in a context-dependent manner: (1S,3R)-RSL3 inhibits GPX4 in the presence of cell cytosol or recombinant human 14-3-3epsilon, an adaptor protein, but does not inhibit recombinant human...
Keywords: | (1S,3R)-2-(2-chloroacetyl)-2,3,4,9-tetrahydro-1-[4-(methoxycarbonyl)phenyl]-1H-pyrido[3,4-b]indole-3-carboxylic acid,... |
Application: | GPX4 inhibitor |
CAS | 1219810-16-8 |
MW: | 440.9 D |
From 43.00€
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Item number: Cay17730-5
Liproxstatin-1 is a ferroptosis inhibitor. It inhibits ferroptotic cell death (IC50 = 22 nM) and lipid peroxidation in mouse embryonic fibroblasts (MEFs) with an inducible knockdown of glutathione peroxidase 4 (Gpx4-/- MEFs) when used at a concentration of 50 nM. Liproxstatin-1 also inhibits ferroptosis induced by...
Keywords: | N-[(3-chlorophenyl)methyl]-spiro[piperidine-4,2'(1'H)-quinoxalin]-3'-amine |
Application: | Ferroptosis inhibitor |
CAS | 950455-15-9 |
MW: | 340.9 D |
From 75.00€
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Item number: ELK-ELK8786.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Mouse GPX4. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Mouse GPX4. Next,...
Keywords: | PHGPx, GPx-4, GSHPx-4, Glutathione peroxidase 4, Phospholipid hydroperoxide glutathione peroxidase |
Application: | ELISA |
Species reactivity: | mouse |
From 365.00€
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Item number: ELK-ELK0719.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Rat GPX4. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Rat GPX4. Next,...
Keywords: | PHGPx, GPx-4, GSHPx-4, Glutathione peroxidase 4, Phospholipid hydroperoxide glutathione peroxidase |
Application: | ELISA |
Species reactivity: | rat |
From 365.00€
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Item number: ELK-ELK4775.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human GPX4. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human GPX4. Next,...
Keywords: | PHGPx, GPx-4, GSHPx-4, EC=1.11.1.12, Glutathione peroxidase 4, Phospholipid hydroperoxide glutathione peroxidase |
Application: | ELISA |
Species reactivity: | human |
From 365.00€
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Item number: Cay39432-1
C18 is a covalent inhibitor of glutathione peroxidase 4 (GPX4, IC50 = 120 nM). It inhibits the growth of MDA-MB-468, BT-549, and MDA-MB-231 breast cancer cells (IC50s = 10, 75, and 12 nM, respectively). C18 (10 and 20 µM) increases lipid peroxidation and oxidized malondialdehyde (MDA) levels in MDA-MB-231 cells, an...
Keywords: | 2-chloro-N-(2,3-dihydro-1,4-benzodioxin-6-yl)-N-(4-fluoro-3,5-dimethoxyphenyl)-acetamide |
Application: | Covalent GPX4 inhibitor |
CAS | 2922824-09-5 |
MW: | 381.8 D |
From 40.00€
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Item number: Cay25180-5
FIN56 is an inducer of ferroptosis and a derivative of CIL56 (Cay-19287). It selectively induces ferroptosis in BJ cells overexpressing oncogenic HRASG12V via acetyl-CoA carboxylase-dependent reduction in expression of GPX4 protein. This effect is reversed by the ferroptosis inhibitors deferoxamine (Cay-14595) and...
Keywords: | N2,N7-dicyclohexyl-9-(hydroxyimino)-9H-fluorene-2,7-disulfonamide |
Application: | Ferroptosis inducer |
CAS | 1083162-61-1 |
MW: | 517.7 D |
From 90.00€
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Item number: Cay38428-1
GPX4 24 is an inhibitor of glutathione peroxidase 4 (GPX4) and a derivative of (1S,3R)-RSL3 (Cay-19288). It covalently binds to GPX4 in 4T1 murine mammary carcinoma cells in a concentration-dependent manner. GPX4 24 induces ferroptosis in GPX4-dependent HT-1080 fibrosarcoma cells (EC50 = 0.16 µM). It increases...
Keywords: | Glutathione Peroxidase 4 24, PHGPx 24, Phospholipid Hydroperoxide Glutathione Peroxidase 24, methyl... |
Application: | GPX4 inhibitor |
MW: | 460.9 D |
From 90.00€
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Item number: Cay25096-1
FINO2 is a ferroptosis-inducing peroxide compound that indirectly inhibits glutathione peroxidase 4 (GPX4) and oxidizes iron. It decreases GPX4 activity and protein levels in vitro but does not act as an active site, allosteric, or covalent inhibitor of GPX4 or alter GPX homeostasis. It also oxidizes iron in vitro,...
Keywords: | (5alpha,8alpha)-8-(1,1-dimethylethyl)-3-methyl-1,2-dioxaspiro[4.5]decane-3-ethanol |
Application: | Ferroptosis-inducing peroxide compound |
CAS | 869298-31-7 |
MW: | 256.4 D |
From 109.00€
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Item number: NSJ-RQ7294
0.5mg/ml if reconstituted with 0.2ml sterile DI water. Glutathione peroxidase 4, also known as GPX4, is an enzyme that in humans is encoded by the GPX4 gene. This gene encodes a member of the glutathione peroxidase protein family. Glutathione peroxidase catalyzes the reduction of hydrogen peroxide, organic...
Keywords: | Anti-GPx-4, Anti-PHGPx, Anti-GSHPx-4, EC=1.11.1.12, Anti-Glutathione peroxidase 4, Anti-Phospholipid hydroperoxide... |
Application: | WB |
Host: | Mouse |
Species reactivity: | human |
755.00€
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Item number: Cay38026-1
LOC1886 is an inhibitor of glutathione peroxidase 4 (GPX4, Ki = 102 µM). It covalently binds to GPX4U46C and inhibits GPX4-mediated reduction of phospholipid hydroperoxides in HT-1080 cell lysates when used at a concentration of 100 µM. LOC1886 (100 µM) increases lipid peroxidation in HT-1080 cells, an effect that...
Keywords: | 1H-imidazol-1-yl(4-methoxy-1H-indol-2-yl)-methanone |
Application: | GPX4 inhibitor |
CAS | 951948-38-2 |
MW: | 241.2 D |
From 40.00€
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