19-O-Acetylchaetoglobosin A

19-O-Acetylchaetoglobosin A is a fungal metabolite originally isolated from C. globosum that has actin polymerization inhibitory and cytotoxic activities. It inhibits actin polymerization in a cell-free assay when used at a concentration of 2 µM. 19-O-Acetylchaetoglobosin A (3.2, 10, and 32 µg/ml) is cytotoxic to HeLa cervical cancer cells.Formal Name: (1E,4S,5E,7R,9E,11aR,14S,14aR,15S,15aR,16aS,16bR)-7-(acetyloxy)-3,4,7,13,14,14a,15,15a,16a,16b-decahydro-14-(1H-indol-3-ylmethyl)-4,6,15,15a-tetramethyl-12H-cyclotridec[d]oxireno[f]isoindole-8,11,12-trione. CAS Number: 50939-69-0. Synonyms: Chaetoglobosin A Acetate. Molecular Formula: C34H38N2O6. Formula Weight: 570.7. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: Acetonitrile: soluble, Methanol: Soluble. SMILES: [H][C@]1(/C=C/C[C@H](C)/C=C2C)[C@]3([H])O[C@@]3([C@H]([C@]4([C@@H](NC([C@]41C(/C=C/C([C@@H]\2OC(C)=O)=O)=O)=O)CC5=CNC6=C5C=CC=C6)[H])C)C. InChi Code: InChI=1S/C34H38N2O6/c1-18-9-8-11-24-31-33(5,42-31)20(3)29-26(16-22-17-35-25-12-7-6-10-23(22)25)36-32(40)34(24,29)28(39)14-13-27(38)30(19(2)15-18)41-21(4)37/h6-8,10-15,17-18,20,24,26,29-31,35H,9,16H2,1-5H3,(H,36,40)/b11-8+,14-13+,19-15+/t18-,20-,24-,26-,29-,30+,31-,33+,34+/m0/s1. InChi Key: AZLAYOMQTNEYFJ-YZYWEBORSA-N. Origin: Fungus/Acremonium sp..