10Z-Hymenialdisine

10Z-Hymenialdisine is a natural marine sponge alkaloid with numerous cellular actions. Most notably, it blocks signaling through the Raf-1/MEK-1/MAPK pathway by potently inhibiting MEK-1 (IC50 = 9 nM). Hymenialdisine also inhibits numerous kinases in vitro, most notably GSK3beta, CDK1/cyclin B, CDK5/p25, CK1, and CDK2/cyclin E (IC50s = 10, 22, 28, 35, and 40 nM, respectively), as well as, less potently, ERK1/2 and several isoforms of PKC. Early studies demonstrated that it suppresses inflammatory gene expression by blocking signaling through NF-kappaB at micromolar concentrations. At similar concentrations, hymenialdisine also blocks bacterial quorum sensing.Formal Name: (4Z)-4-(2-amino-1,5-dihydro-5-oxo-4H-imidazol-4-ylidene)-2-bromo-4,5,6,7-tetrahydro-pyrrolo[2,3-c]azepin-8(1H)-one. CAS Number: 82005-12-7. Molecular Formula: C11H10BrN5O2. Formula Weight: 324.1. Purity: >97%. Formulation: (Request formulation change), A solid. Solubility: DMSO: soluble. SMILES: BrC(N1)=CC2=C1C(NCC/C2=C3C(N=C(N)N\3)=O)=O. InChi Code: InChI=1S/C11H10BrN5O2/c12-6-3-5-4(7-10(19)17-11(13)16-7)1-2-14-9(18)8(5)15-6/h3,15H,1-2H2,(H,14,18)(H3,13,16,17,19)/b7-4-. InChi Key: ATBAETXFFCOZOY-DAXSKMNVSA-N. Origin: Sponge/Axinella carteri.