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Hinokitiol is a tropolone originally isolated from the heart wood of T. plicata that has diverse biological activities, including antifungal, antibacterial, and antiproliferative properties. It inhibits proliferation of HCT-116 and SW-620 colon cancer cells (IC50s = 4.5 and 4.4 µM, respectively), arrests the cell cycle, and induces apoptosis. In mouse xenograft models of colon cancer, hinokitiol (100 mg/kg) decreases tumor volume and weight. It also has effects on platelets, inhibiting thrombus formation in mice and selectively inhibiting platelet-type 12-lipoxygenase (12-LO, IC50 = 0.1 µM) over leukocyte-type 12-LO (IC50 = 50 µM) in vitro.Formal Name: 2-hydroxy-4-(1-methylethyl)-2,4,6-cycloheptatrien-1-one. CAS Number: 499-44-5. Synonyms: NSC 18804, beta-Thujaplicin, 4-isopropyl Tropolone. Molecular Formula: C10H12O2. Formula Weight: 164.2. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 12.5 mg/ml, DMSO: 30 mg/ml, DMSO:PBS(pH 7.2) (1:4): 0.2 mg/ml, Ethanol: 20 mg/ml. lambdamax: 238, 320 nm. SMILES: O=C1C(O)=CC(C(C)C)=CC=C1. InChi Code: InChI=1S/C10H12O2/c1-7(2)8-4-3-5-9(11)10(12)6-8/h3-7H,1-2H3,(H,11,12). InChi Key: FUWUEFKEXZQKKA-UHFFFAOYSA-N.
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the usability of this website, serve for direct advertising or simplify interaction with other websites and social networks, will only be used with your consent.
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