Bottromycin A2

Bottromycin A2 is an antibiotic originally isolated from Streptomyces. It blocks the binding of aminoacyl-tRNA to the A site of the 50S ribosome, inhibiting protein synthesis. Bottromycin A2 is active against clinical isolates of methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococci with MIC values of 1 and 0.5 µg/ml, respectively.Formal Name: (3R)-N-[(2S)-2-[[glycyl-(3R)-3-methyl-L-prolyl-L-valyl]amino]-1-imino-3,3-dimethylbutyl]-3-methyl-L-valyl-(betaS)-beta-methyl-L-phenylalanyl-3-(2-thiazolyl)-beta-alanine, cyclic (1->1')-imine, methyl ester. CAS Number: 15005-62-6. Molecular Formula: C42H62N8O7S. Formula Weight: 823.1. Purity: >80%. Formulation: (Request formulation change), A solid. Solubility: Ether: soluble, Methanol: soluble, Water: soluble. SMILES: O=C1[C@@]2([H])N(CC[C@H]2C)C(C/N=C([C@@H](NC([C@@H](N1)C(C)C)=O)C(C)(C)C)/N[C@@H](C(C)(C)C)C(N[C@H](C(N[C@@H](C3=NC=CS3)CC(OC)=O)=O)[C@H](C4=CC=CC=C4)C)=O)=O. InChi Code: InChI=1S/C42H62N8O7S/c1-23(2)30-36(53)49-33(41(5,6)7)35(44-22-28(51)50-19-17-24(3)32(50)38(55)46-30)48-34(42(8,9)10)39(56)47-31(25(4)26-15-13-12-14-16-26)37(54)45-27(21-29(52)57-11)40-43-18-20-58-40/h12-16,18,20,23-25,27,30-34H,17,19,21-22H2,1-11H3,(H,44,48)(H,45,54)(H,46,55)(H,47,56)(H,49,53)/t24-,25+,27-,30+,31+,32+,33-,34-/m1/s1. InChi Key: KSIZLOPUXFSFNR-XZNJZDOZSA-N. Origin: Bacterium/Streptomyces No. 3668-L2.