Anisomycin

Anisomycin is a pyrrolidine antibiotic produced by S. griseolus that inhibits protein and DNA synthesis. It activates stress-activated protein kinase, MAP kinase, and other signal transduction pathways. At 30 mg/kg, anisomycin displays immunosuppressive activity superior to that of Cyclosporine A, blocking T cell proliferation in skin-transplanted mice. Through a caspase-8-dependent pathway, anisomycin acts as a potent and specific anoikis sensitizer of malignant epithelial cells resistant to apoptosis upon detachment from the ECM, preventing distal tumor formation in a mouse model of prostate cancer metastases.Formal Name: 2-[(4-methoxyphenyl)methyl]-3-acetate-(2R,3S,4S)-3,4-pyrrolidinediol. CAS Number: 22862-76-6. Synonyms: Flagecidin, NSC 76712, Wuningmeisu C. Molecular Formula: C14H19NO4. Formula Weight: 265.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMSO: 20 mg/ml, Ethanol: 1 mg/ml, PBS (pH 7.2): 0.5 mg/ml. lambdamax: 225, 277, 284 nm. SMILES: O[C@H]1CN[C@H](CC2=CC=C(OC)C=C2)[C@@H]1OC(C)=O. InChi Code: InChI=1S/C14H19NO4/c1-9(16)19-14-12(15-8-13(14)17)7-10-3-5-11(18-2)6-4-10/h3-6,12-15,17H,7-8H2,1-2H3/t12-,13+,14+/m1/s1. InChi Key: YKJYKKNCCRKFSL-RDBSUJKOSA-N.