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Polymyxin B2 (sulfate)
Item number: Cay39720-1
Polymyxin B2 is an antibiotic and a major constituent of the cationic lipopeptide antibiotic polymyxin B (Cay-14157) originally isolated from B. polymyxa. It is active against P. aeruginosa, A. baumannii, K. pneumoniae, and E. cloacae strains (MICs = 1-2, 0.5-1, 0.25-0.5, and 0.25-1 µg/ml, respectively). In vivo,...
| Application: | Antibiotic, major polymyxin B constituent, cell membrane function inhibitor |
| CAS | 108965-69-1 |
| MW: | 1189.5 D |
From 409.00€
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G418, sulfate
Item number: AG-CN2-0030-G005
Isolated from Micromonospora rhodorangea. Antibiotic. Cytotoxic to prokaryotic and eukaryotic cells by inhibiting the protein synthesis. Apoptosis inducer. Widely employed in the selection of eukaryotic expression vectors, in combination with either aminoglycoside phosphotransferase 3' or APH II. Antiviral. Assay:...
| Keywords: | Geneticin, Antibiotic G418, BRN 1669188 |
| Application: | Apoptosis inducer |
| CAS | 108321-42-2 |
From 33.00€
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(+)-Aphidicolin
Item number: Cay14007-1
(+)-Aphidicolin is a natural tetracyclic diterpene first isolated from the fungus C. aphidicola and shown to have antiviral activity against herpes simplex. In eukaryotic cells, it is a cell-permeable, reversible inhibitor of DNA replication, specifically blocking the activity of DNA polymerases alpha, delta, and...
| Keywords: | ICI 69653, NSC 234714,... |
| Application: | Eucaryotic nuclear DNA replication inhibitor |
| CAS | 38966-21-1 |
| MW: | 338.5 D |
From 115.00€
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Mithramycin A
Item number: Cay11434-1
Mithramycin A is a DNA-binding, anti-tumor and neuroprotective antibiotic originally isolated from S. grieseus that has long been used as a chemotherapeutic agent. It mediates its protective function, in part, by regulating acetylation of histones or transcription factors and, thereby, chromatin accessibility to...
| Keywords: | A 2371, Antibiotic LA 7017, Aureolic Acid, NSC 24559, PA 144, Plicamycin,... |
| Application: | Antibiotic, SP1 inhibitor |
| CAS | 18378-89-7 |
| MW: | 1085.2 D |
From 66.00€
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Leptomycin B
Item number: Cay10004976-5
Leptomycin B is a potent inhibitor of the nuclear export of proteins. It directly blocks the interaction of CRM1 (exportin 1) with nuclear export signals (NES), preventing the export of a broad range of proteins. Leptomycin B will also indirectly inhibit the export of mRNA from the nucleus by blocking the nuclear...
| Keywords: | Elactocin, LMB, Mantuamycin, NSC 364372,... |
| Application: | Nuclear export blocker |
| CAS | 87081-35-4 |
| MW: | 540.7 D |
From 48.00€
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Doxycycline (hyclate)
Item number: Cay14422-1
Doxycycline is a broad-spectrum tetracycline antibiotic. It inhibits bacterial protein synthesis by binding to ribosomes. Doxycycline also selectively inhibits human matrix metalloproteinase-8 (MMP-8) and MMP-13 over MMP-1 with 50, 60, and 5% inhibition, respectively, when used at a concentration of 30 µM. It can be...
| Keywords: | (4S,4aR,5S,5aR,6R,12aS)-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-... |
| Application: | Antibiotic |
| CAS | 24390-14-5 |
| MW: | 1025.9 D |
From 43.00€
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Minocycline (hydrochloride hydrate)
Item number: Cay14454-100
Minocycline is a broad-spectrum tetracycline antibiotic. It is active against E. faecium in vitro (MIC = 16 mg/L). Minocycline (20 mg/kg every 12 hours) reduces the number of bacteria in the lung in a mouse model of multidrug resistant A. baumannii-induced pneumonia. It reduces spinal cord lesion size and improves...
| Keywords: | NSC 141993,... |
| Application: | Antibiotic |
| MW: | 493.9 D |
From 43.00€
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Validamycin A
Item number: Cay15326-1
Validamycin A is a fungicidal agent used to protect rice plants against sheath blight caused by the pathogenic fungus, R. solani, due to its ability to inhibit trehalase, a trehalose-hydrolizing enzyme (Ki = 1.9 nM, IC50 = 0.7 µM). It is also effective against the growth and sporulation of R. cerealis, F. culmorum,...
| Keywords: | Validacin,... |
| Application: | Fungicidal agent, trehalase inhibitor |
| CAS | 37248-47-8 |
| MW: | 497.5 D |
From 62.00€
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Hygromycin B
Item number: Cay36462-100
Hygromycin B is an aminoglycoside antibiotic that has been found in S. hygroscopicus. It is active against E. coli (MIC = 150 µg/ml) and cytotoxic to both prokaryotic and eukaryotic cells via inhibition of protein synthesis. Hygromycin B has commonly been used in molecular and cell biology applications to select for...
| Keywords: | Hygrovetine,... |
| Application: | Aminoglycoside antibiotic, protein synthesis inhibitor |
| CAS | 31282-04-9 |
| MW: | 527.5 D |
From 35.00€
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Ceforanide
Item number: Cay36075-100
Ceforanide is a cephalosporin antibiotic. It is active against the Gram-positive bacteria S. pyogenes, S. pneumoniae, V. streptococci, S. aureus, and S. epidermidis (MICs = 0.5, 0.2-0.5, 2, 8, and 6.2 µg/ml, respectively), as well as the Gram-negative bacteria E. coli, P. mirabilis, and K. pneumoniae (MIC50s = 1.6,...
| Keywords: | BL-S 786,... |
| Application: | Cephalosporin antibiotic, antibacterial, cell wall biosynthesis inhibitor |
| CAS | 60925-61-3 |
| MW: | 519.6 D |
From 240.00€
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Blasticidin S (hydrochloride)
Item number: Cay14499-50
Blasticidin S is a peptidyl nucleoside antibiotic. It was first isolated from S. griseochromogenes. The structure of the pentahydrate form was determined using diffractometer data and, similar to the antibiotic amicetin, the hydrophilic and hydrophobic groups lie on either side of the molecule. It has since been...
| Keywords: | 4-[[(3S)-3-amino-5-[(aminoiminomethyl)methylamino]-1-oxopentyl]amino]-1-(4-amino-2-oxo-1(2H)-pyrimidinyl)-1,2,3,4-tetradeo... |
| Application: | Antibiotic |
| CAS | 3513-03-9 |
| MW: | 458.9 D |
From 54.00€
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Antimycin A
Item number: LKT-A5378.10
White powder. An inhibitor of mitochondrial respiratory chain complex III. Induces apoptosis in cell cultures.
| Application: | Apoptosis inducer |
| CAS | 1397-94-0 |
| MW: | 548,63 D |
From 189.00€
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