1-Deoxynojirimycin (hydrochloride)

1-Deoxynojirimycin (hydrochloride)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay10011718-1 1 mg -

6 - 10 business days*

29.00€
Cay10011718-5 5 mg -

6 - 10 business days*

130.00€
Cay10011718-10 10 mg -

6 - 10 business days*

230.00€
Cay10011718-50 50 mg -

6 - 10 business days*

1,007.00€
 
1-Deoxynojirimycin (1-dNM) (hydrochloride), produced by Bacillus species, is a glucose analog... more
Product information "1-Deoxynojirimycin (hydrochloride)"
1-Deoxynojirimycin (1-dNM) (hydrochloride), produced by Bacillus species, is a glucose analog that potently inhibits alpha-glucosidase I and II. It prevents the formation of complex N-linked oligosaccharides in yeast and intact mammalian cells by inhibiting both alpha-glucosidase I and II with IC50 values of ~2 µM. The FDA has granted orphan drug designation to dNM (hydrochloride) for the treatment of Pompe disease, an inherited lysosomal storage disorder caused by a mutation that alters the structure and stability of alpha-glucosidase. 1-dNM, at a concentration of 0.4 mM, also inhibits virus spread in HIV-infected lymphocyte cultures by interfering with alpha-glucosidase activity. Formal Name: 2R-(hydroxymethyl)-3R,4R,5S-piperidinetriol, monohydrochloride. CAS Number: 73285-50-4. Synonyms: 1-dNM, Moranoline. Molecular Formula: C6H13NO4 . HCl. Formula Weight: 199.6. Purity: >95%. Formulation: A crystalline solid. Solubility: DMSO: 10 mg/ml, PBS (pH 7.2): 1 mg/ml. SMILES: O[C@H]1[C@H](O)[C@@H](O)CN[C@@H]1CO.Cl. InChi Code: InChI=1S/C6H13NO4.ClH/c8-2-3-5(10)6(11)4(9)1-7-3,/h3-11H,1-2H2,1H/t3-,4+,5-,6-,/m1./s1. InChi Key: ZJIHMALTJRDNQI-VFQQELCFSA-N.
Keywords: 1-dNM, Moranoline, 2R-(hydroxymethyl)-3R,4R,5S-piperidinetriol, monohydrochloride
Supplier: Cayman Chemical
Supplier-Nr: 10011718

Properties

Application: Glucosidase inhibitor
MW: 199.6 D
Formula: C6H13NO4 . HCl
Purity: >95%
Format: Crystalline Solid

Database Information

CAS : 73285-50-4| Find alternatives
KEGG ID : K05546 | Find alternatives

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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