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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
G-RTES00127.96 | 96 assays | - |
9 - 20 business days* |
694.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
ELISA Type: CLIA. Sensitivity: 0.188 ng/mL. Range: 0.313--20 ng/mL. Protein function: Functions... more
Product information "Rat CLU (Clusterin) CLIA Kit"
ELISA Type: CLIA. Sensitivity: 0.188 ng/mL. Range: 0.313--20 ng/mL. Protein function: Functions as extracellular chaperone that prevents aggregation of non native proteins. Prevents stress-induced aggregation of blood plasma proteins. Inhibits formation of amyloid fibrils by APP, APOC2, B2M, CALCA, CSN3, SNCA and aggregation-prone LYZ variants (in vitro). Does not require ATP. Maintains partially unfolded proteins in a state appropriate for subsequent refolding by other chaperones, such as HSPA8/HSC70. Does not refold proteins by itself. Binding to cell surface receptors triggers internalization of the chaperone-client complex and subsequent lysosomal or proteasomal degradation. When secreted, protects cells against apoptosis and against cytolysis by complement. Intracellular forms interact with ubiquitin and SCF (SKP1- CUL1-F-box protein) E3 ubiquitin-protein ligase complexes and promote the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes proteasomal degradation of COMMD1 and IKBKB. Modulates NF-kappa-B transcriptional activity. Following stress, promotes apoptosis. Inhibits apoptosis when associated with the mitochondrial membrane by interference with BAX-dependent release of cytochrome c into the cytoplasm. Plays a role in the regulation of cell proliferation. An intracellular form suppresses stress-induced apoptosis by stabilizing mitochondrial membrane integrity through interaction with HSPA5. Secreted form does not affect caspase or BAX-mediated intrinsic apoptosis and TNF-induced NF-kappa-B-activity. Secreted form act as an important modulator during neuronal differentiation through interaction with STMN3 (PubMed:16038898). Plays a role in the clearance of immune complexes that arise during cell injury. [The UniProt Consortium]
Supplier: | Assay Genie |
Supplier-Nr: | RTES00127 |
Properties
Application: | CLIA |
Species reactivity: | rat |
Format: | Solid Phase |
Database Information
KEGG ID : | K17252 | Matching products |
UniProt ID : | P05371 | Matching products |
Gene ID | GeneID 24854 | Matching products |
Handling & Safety
Storage: | vT |
Shipping: | +4°C (International: +4°C) |
Signal Word: | Warning |
GHS Hazard Pictograms: |
|
H Phrases: | H315, H319 |
P Phrases: | P264, P280 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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