IL-6 (murine) ELISA Set

Diaclone ELISA Sets include capture and biotinylated detection antibody, one standard per plate, Streptavidin-HRP, TMB, and detailed procedure including buffer composition., Assay Range: 15.6-500 pg/ml, Sensitivity: 10 pg/ml, Cross reaction: No cross reactivity with other murine cytokines, Incubation time: From sample to end 3h50, Sample Types: Serum, Cell culture supernatant, Sample Size: 100 µl Protein function: Cytokine with a wide variety of biological functions in immunity, tissue regeneration, and metabolism (Probable). Binds to IL6R, then the complex associates to the signaling subunit IL6ST/gp130 to trigger the intracellular IL6-signaling pathway (PubMed:8910279). The interaction with the membrane-bound IL6R and IL6ST stimulates 'classic signaling', whereas the binding of IL6 and soluble IL6R to IL6ST stimulates 'trans-signaling'. Alternatively, 'cluster signaling' occurs when membrane-bound IL6:IL6R complexes on transmitter cells activate IL6ST receptors on neighboring receiver cells (PubMed:27893700). [The UniProt Consortium]