Human TERT (Telomerase Reverse Transcriptase) CLIA Kit

Human TERT (Telomerase Reverse Transcriptase) CLIA Kit
Item number Size Datasheet Manual SDS Delivery time Quantity Price
G-HUES00451.96 96 assays -

9 - 20 business days*

694.00€
 
ELISA Type: CLIA. Sensitivity: 18.75 pg/mL. Range: 31.25--2000 pg/mL. Protein function:... more
Product information "Human TERT (Telomerase Reverse Transcriptase) CLIA Kit"
ELISA Type: CLIA. Sensitivity: 18.75 pg/mL. Range: 31.25--2000 pg/mL. Protein function: Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nucleotide telomeric repeat unit, 5'-TTAGGG-3'. The catalytic cycle involves primer binding, primer extension and release of product once the template boundary has been reached or nascent product translocation followed by further extension. More active on substrates containing 2 or 3 telomeric repeats. Telomerase activity is regulated by a number of factors including telomerase complex- associated proteins, chaperones and polypeptide modifiers. Modulates Wnt signaling. Plays important roles in aging and antiapoptosis. [The UniProt Consortium]
Keywords: TP2, EST2, TERT, HEST2, Telomerase catalytic subunit, Telomerase-associated protein 2, Telomerase reverse transcriptase
Supplier: Assay Genie
Supplier-Nr: HUES00451

Properties

Application: CLIA
Species reactivity: human
Format: Solid Phase

Handling & Safety

Storage: vT
Shipping: +4°C (International: +4°C)
Signal Word: Warning
GHS Hazard Pictograms:
H Phrases: H315, H319
P Phrases: P264, P280
Caution
Our products are for laboratory research use only: Not for administration to humans!
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