Human STUB1 (E3ubiquitin-proteinligaseCHIP) ELISA Kit

Human STUB1 (E3ubiquitin-proteinligaseCHIP) ELISA Kit
Item number Size Datasheet Manual SDS Delivery time Quantity Price
E-EL-H5533.96 96 wells -

7 - 16 business days*

483.00€
 
The kit is a Sandwich enzyme immunoassay for in vitro quantitative measurement of STUB1 in serum,... more
Product information "Human STUB1 (E3ubiquitin-proteinligaseCHIP) ELISA Kit"
The kit is a Sandwich enzyme immunoassay for in vitro quantitative measurement of STUB1 in serum, plasma and other biological fluids. Detection Range: 31.25--2000pg/mL. Sensitivity: 18.75pg/mL. Protein function: E3 ubiquitin-protein ligase which targets misfolded chaperone substrates towards proteasomal degradation. Collaborates with ATXN3 in the degradation of misfolded chaperone substrates: ATXN3 restricting the length of ubiquitin chain attached to STUB1/CHIP substrates and preventing further chain extension. Ubiquitinates NOS1 in concert with Hsp70 and Hsp40. Modulates the activity of several chaperone complexes, including Hsp70, Hsc70 and Hsp90. Mediates transfer of non-canonical short ubiquitin chains to HSPA8 that have no effect on HSPA8 degradation. Mediates polyubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair: catalyzes polyubiquitination by amplifying the HUWE1/ARF- BP1-dependent monoubiquitination and leading to POLB-degradation by the proteasome. Mediates polyubiquitination of CYP3A4. Ubiquitinates EPHA2 and may regulate the receptor stability and activity through proteasomal degradation. Acts as a co-chaperone for HSPA1A and HSPA1B chaperone proteins and promotes ubiquitin- mediated protein degradation (PubMed:27708256). Negatively regulates the suppressive function of regulatory T-cells (Treg) during inflammation by mediating the ubiquitination and degradation of FOXP3 in a HSPA1A/B-dependent manner (PubMed:23973223). Negatively regulates TGF-beta signaling by modulating the basal level of SMAD3 via ubiquitin-mediated degradation (PubMed:24613385). [The UniProt Consortium]
Keywords: Antigen NY-CO-7, CLL-associated antigen KW-8, E3 ubiquitin-protein ligase CHIP, RING-type E3 ubiquitin transferase CHIP, STIP1 homology and U box-containing protein 1, Carboxy terminus of Hsp70-interacting protein
Supplier: Elabscience
Supplier-Nr: E-EL-H5533

Properties

Application: ELISA
Species reactivity: human
Format: Solid Phase

Handling & Safety

Storage: vT
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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