Human RSPO2 (R-spondin-2) ELISA Kit (HUFI06699)

Human RSPO2 (R-spondin-2) ELISA Kit from Assay Genie is a pre-coated immunoassay with a high sensitivity and broad range and has been designed to measure Human RSPO2 (R-spondin-2) in serum, plasma & cell culture supernatant samples. The Human RSPO2 (R-spondin-2) ELISA Kit accurately measures natural Human RSPO2 (R-spondin-2) levels quantified versus standard curves obtained and is based on antibodies raised against a recombinant Human RSPO2 (R-spondin-2) peptide. Protein function: Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway (PubMed:21909076, PubMed:21727895, PubMed:22615920). During embryonic development, plays a crucial role in limb specification, amplifying the Wnt signaling pathway independently of LGR4-6 receptors, possibly by acting as a direct antagonistic ligand to RNF43 and ZNRF3, hence governing the number of limbs an embryo should form (PubMed:29769720). [The UniProt Consortium]