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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
G-HUFI04505.96 | 96 assays | - | - | - |
9 - 20 business days* |
641.00€
|
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You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Human DTX3L (E3 ubiquitin-protein ligase DTX3L) ELISA Kit from Assay Genie is a pre-coated... more
Product information "Human DTX3L (E3 ubiquitin-protein ligase DTX3L) ELISA Kit (HUFI04505)"
Human DTX3L (E3 ubiquitin-protein ligase DTX3L) ELISA Kit from Assay Genie is a pre-coated immunoassay with a high sensitivity and broad range and has been designed to measure Human DTX3L (E3 ubiquitin-protein ligase DTX3L) in serum, plasma & cell culture supernatant samples. The Human DTX3L (E3 ubiquitin-protein ligase DTX3L) ELISA Kit accurately measures natural Human DTX3L (E3 ubiquitin-protein ligase DTX3L) levels quantified versus standard curves obtained and is based on antibodies raised against a recombinant Human DTX3L (E3 ubiquitin-protein ligase DTX3L) peptide. Protein function: E3 ubiquitin-protein ligase which, in association with ADP- ribosyltransferase PARP9, plays a role in DNA damage repair and in interferon-mediated antiviral responses (PubMed:12670957, PubMed:19818714, PubMed:26479788, PubMed:23230272). Monoubiquitinates several histones, including histone H2A, H2B, H3 and H4 (PubMed:28525742). In response to DNA damage, mediates monoubiquitination of 'Lys-91' of histone H4 (H4K91ub1) (PubMed:19818714). The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such as H4 'Lys-20' methylation (H4K20me) (PubMed:19818714). PARP1-dependent PARP9-DTX3L- mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites (PubMed:23230272). By monoubiquitinating histone H2B H2BC9/H2BJ and thereby promoting chromatin remodeling, positively regulates STAT1- dependent interferon-stimulated gene transcription and thus STAT1- mediated control of viral replication (PubMed:26479788). Independently of its catalytic activity, promotes the sorting of chemokine receptor CXCR4 from early endosome to lysosome following CXCL12 stimulation by reducing E3 ligase ITCH activity and thus ITCH-mediated ubiquitination of endosomal sorting complex required for transport ESCRT-0 components HGS and STAM (PubMed:24790097). In addition, required for the recruitment of HGS and STAM to early endosomes (PubMed:24790097). In association with PARP9, plays a role in antiviral responses by mediating 'Lys-48'-linked ubiquitination of encephalomyocarditis virus (EMCV) and human rhinovirus (HRV) C3 proteases and thus promoting their proteosomal-mediated degradation (PubMed:26479788). [The UniProt Consortium]
Keywords: | BBAP, DTX3L, Rhysin2, Rhysin-2, Protein deltex-3-like, E3 ubiquitin-protein ligase DTX3L, B-lymphoma- and BAL-associated protein, RING-type E3 ubiquitin transferase DTX3L |
Supplier: | Assay Genie |
Supplier-Nr: | HUFI04505 |
Properties
Application: | Sandwich ELISA |
Species reactivity: | human |
Database Information
KEGG ID : | K06058 | Matching products |
UniProt ID : | Q8TDB6 | Matching products |
Handling & Safety
Storage: | +4°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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