Human Cyr61 (Cysteine Rich Protein, Angiogenic Inducer 61) ELISA Kit

The kit is a Sandwich enzyme immunoassay for in vitro quantitative measurement of Cyr61 in serum, plasma and other biological fluids. Detection Range: 31.25--2000pg/mL. Sensitivity: 18.75pg/mL. Protein function: Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up- regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5. CYR61-mediated gene regulation is dependent on heparin-binding. Down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1. Promotes cell adhesion and adhesive signaling through integrin alpha-6/beta-1, cell migration through integrin alpha-v/beta-5 and cell proliferation through integrin alpha-v/beta-3. [The UniProt Consortium]