Human C4a (Complement Component 4a) ELISA Kit

The kit is a Sandwich enzyme immunoassay for in vitro quantitative measurement of C4a in serum, plasma and other biological fluids. Detection Range: 1.56--100ng/mL. Sensitivity: 0.94ng/mL. Protein function: Non-enzymatic component of C3 and C5 convertases and thus essential for the propagation of the classical complement pathway. Covalently binds to immunoglobulins and immune complexes and enhances the solubilization of immune aggregates and the clearance of IC through CR1 on erythrocytes. C4A isotype is responsible for effective binding to form amide bonds with immune aggregates or protein antigens, while C4B isotype catalyzes the transacylation of the thioester carbonyl group to form ester bonds with carbohydrate antigens. [The UniProt Consortium]