2'3'-cGAMP ELISA Kit

Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay501700-96S 96 so-wells -

1 - 10 business days

494.00€
Cay501700-96 96 st-wells -

1 - 10 business days

494.00€
 
Cyclic GMP-AMP synthase (cGAS) is a cytosolic DNA sensor that detects the presence of nucleic... more
Product information "2'3'-cGAMP ELISA Kit"
Cyclic GMP-AMP synthase (cGAS) is a cytosolic DNA sensor that detects the presence of nucleic acids in the cytosol of mammalian cells as an indicator of bacterial or viral infection. cGAS catalyzes the synthesis of a second messenger, 2'3'-cGAMP, from cytosolic ATP and GTP in response to dsDNA binding. 2'3'-cGAMP then binds tightly to the adaptor protein STING (stimulator of interferon genes), resulting in the recruitment of TBK1 and subsequent IRF3 phosphorylation. IRF3 induces the transcription and translation type I interferon, a potent antiviral cytokine. Activation of cGAS and the production of 2'3'-cGAMP are important in host defense, but also may play role in autoimmune or inflammatory diseases. Modulation of cGAS activity, with subsequent inhibition of induction of 2'3'-cGAMP formation is an active target of pharmacological intervention. Powered by BIOLOG Life Science Institute.
Keywords: 2'3'-cGAMP EIA Kit, 2'3'-Cyclic GMP-AMP, Guanosine-Adenosine 2',3'-cyclic monophosphate
Supplier-Nr: 501700-96S

Properties

Application: ELISA
Format: Solid Phase

Database Information

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Signal Word: Danger
GHS Hazard Pictograms:
H Phrases: H315, H350
P Phrases: P201, P202, P264, P280, P321, P302+P352, P308+P313, P332+P313, P362+P364, P405, P501
Caution
Our products are for laboratory research use only: Not for administration to humans!
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