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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
BPS-78891 | 384 rxns | - | - |
3 - 15 business days* |
3,343.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
The JAK1 (JH2 Pseudokinase Domain) Inhibitor Screening Assay Kit is a fluorescence... more
Product information "JAK1 (JH2 Pseudokinase Domain) Inhibitor Screening Assay Kit"
The JAK1 (JH2 Pseudokinase Domain) Inhibitor Screening Assay Kit is a fluorescence polarization-based assay designed for screening and profiling small molecules that displace the fluorescently labeled probe (JH2 probe 1) from the JH2 pseudokinase domain of JAK1. This kit comes in a convenient 384-well format, with enough recombinant human JAK1 (JH2 Pseudokinase Domain), buffer, and fluorescently labeled JH2 probe 1 for 384 reactions. This assay requires a fluorescent microplate reader capable of measuring fluorescence polarization (FP) to read the FP signal. For more information on the principles of FP, visit bpsbioscience.com/pub/media/ebook_pdf/f/p/fp_assays.pdf. The assay is based on the competition between the test compound and the JH2 probe for the purified JAK1 (JH2 Pseudokinase Domain). JH2 probe 1 is incubated with JAK1 (JH2 Pseudokinase Domain) in the presence or absence of inhibitor. When the JH2 probe 1 is bound to the JH2 pseudokinase domain it has high FP due to its restricted movement. A competitive inhibitor prevents the probe from binding to the JH2 pseudokinase domain, therefore most of the probe is in free form and has low FP. Compared to a control without inhibitor, FP decreases proportionally to the inhibitor concentration.
Keywords: | JAK1, JAK1A, JAK-1, Janus kinase 1, Tyrosine-protein kinase JAK1, |
Supplier: | BPS Bioscience |
Supplier-Nr: | 78891 |
Properties
Application: | Small molecule screening/profiling |
Species reactivity: | human |
Format: | Homog. |
Database Information
KEGG ID : | K11217 | Matching products |
UniProt ID : | P23458 | Matching products |
Gene ID | GeneID 3716 | Matching products |
Handling & Safety
Storage: | -80°C |
Shipping: | -80°C (International: °C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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