Anti-Iglambda Light Chain (mouse) Rabbit Monoclonal Antibody (Clone RM110)

Iglambda light chain is one type of light chain found in immunoglobulins, which are part of the immunoglobulin superfamily of glycoproteins that plays a central role in the adaptive immune response. Immunoglobulins are produced by B cells and later secreted by plasma cells as antibodies. They are composed of two heavy chains of approximately 50 kDa each and two light chains of approximately 25 kDa each. The heavy chains are linked together by disulfide bonds to form an Fc region and also combine with the light chains to form the Fab region, which mediate receptor and antigen binding, respectively. Mammalian immunoglobulins contain either Igkappa or Iglambda light chains each of which are composed of a constant and variable domain. The ratio of Igkappa to Iglambda light chain containing antibodies varies between species, with ratios of 20:1, 2:1, and 1:20 in mice, humans, and cattle, respectively. In systemic amyloidosis, a clonal population of plasma cells produces light chains that form amyloid fibrils, and the type of free light chains (FLCs) produced is predominantly Iglambda with an Igkappa to Iglambda ratio of 1:3 or, in amyloidosis patients with nephrotic-range proteinuria, 1:5. Cayman's Iglambda Light Chain (mouse) Rabbit Monoclonal Antibody (Clone RM110) can be used for ELISA and Western blot (WB, non-reducing conditions) applications. The antibody recognizes the Iglambda light chain from mouse samples.Synonyms: Immunoglobulin lambda Light Chain. Immunogen: Mouse IgMlambda. Clone Designation: RM110. Formulation: (Request formulation change), 100 µg of protein A-affinity purified monoclonal antibody. Storage Buffer: PBS with 50% glycerol, 1% BSA, and 0.09% sodium azide. Host: Rabbit. Isotype: IgG. Applications: ELISA, WB (non-reducing conditions). Cross Reactivity: (-) Igkappa light chain, (-) Goat IgG, (-) Human IgG, (-) Rat IgG.