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AZD 9496
AZD 9496

Item number: Cay21805-1

AZD 9496 is a potent and selective estrogen receptor downregulator (SERD) with an IC50 value of 0.138 nM for estrogen receptor alpha (ERalpha) downregulation. It is selective for ERalpha compared to other nuclear hormone receptors with IC50 values of 0.0008, 0.54, 9.2, and 30 µM for ERalpha, progesterone receptor (PR), glucocorticoid receptor (GR), and androgen receptor...
Application: Estrogen receptor downregulator & antagonist
CAS 1639042-08-2
MW: 442.5 D
Purity: >98%
Format: Crystalline Solid
From 37.00€
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7-hydroxy Coumarin sulfate (potassium salt)
7-hydroxy Coumarin sulfate (potassium salt)

Item number: Cay20892-5

7-hydroxy Coumarin sulfate is a phase II metabolite of coumarin that can be used as an internal standard for the analysis of 7-hydroxy coumarin metabolism using GC- or LC-MS.
Application: 7-hydroxycoumarin metabolite
CAS 1135316-80-1
MW: 280.3 D
Purity: >98%
Format: Crystalline Solid
From 37.00€
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Coenzyme Q1
Coenzyme Q1

Item number: Cay18741-5

Cooenzyme Q10 (CoQ10) is a component of the electron transport chain and participates in aerobic cellular respiration, generating energy in the form of ATP. CoQ1 is an amphipathic CoQ10 homolog that has a tail consisting of five isoprene units. It has been used as an electron acceptor to study a range of oxidoreductases as isolated enzymes, in subcellular fractions, in...
Application: Amphipathic CoQ10 homolog
CAS 727-81-1
MW: 250.3 D
Purity: >98%
Format: Solution
From 44.00€
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PD 153035
PD 153035

Item number: Cay18080-1

PD 153035 is a potent, reversible inhibitor of EGFR kinase (Ki = 5.2 pM, IC50 = 29 pM). It less effectively inhibits HER2 (IC50 = 2.3 µM) and has little effect on several other receptor and non-receptor tyrosine kinases. PD 153035 has been shown to rapidly suppress autophosphorylation of EGFR in fibroblasts and human epidermoid carcinoma cells, as well as to selectively...
Application: EGFR inhibitor
CAS 153436-54-5
MW: 360.2 D
Purity: >98%
Format: Crystalline Solid
From 32.00€
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MCC950
MCC950

Item number: Cay17510-25

NOD-like receptor (NLR) pyrin domain-containing protein 3 (NLRP3) senses pathogen-derived, environmental, and host-derived factors and initiates the formation of inflammasomes, complexes involved in complex diseases including multiple sclerosis, type 2 diabetes, Alzheimer's disease, and atherosclerosis. MCC950 is a selective inhibitor of NLRP3, blocking the release of...
Application: NLRP3 inhibitor
CAS 210826-40-7
MW: 404.5 D
Purity: >98%
Format: Crystalline Solid
From 82.00€
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GSK1016790A
GSK1016790A

Item number: Cay17289-5

Transient receptor potential vanilloid 4 (TRPV4) is a nonselective cation channel thought to be involved in osmoregulation, hyperalgesia, and control of epithelial cell volume. GSK1016790A is a TRPV4 agonist that has been reported to elicit calcium influx in HEK cells expressing mouse or human TRPV4 (EC50s = 18 and 2.1 nM, respectively). It has been used to demonstrate a...
Application: TRPV4 agonist
CAS 942206-85-1
MW: 655.6 D
Purity: >98%
Format: Crystalline Solid
From 32.00€
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GSK1016790A
GSK1016790A

Item number: Cay17289-1

Transient receptor potential vanilloid 4 (TRPV4) is a nonselective cation channel thought to be involved in osmoregulation, hyperalgesia, and control of epithelial cell volume. GSK1016790A is a TRPV4 agonist that has been reported to elicit calcium influx in HEK cells expressing mouse or human TRPV4 (EC50s = 18 and 2.1 nM, respectively). It has been used to demonstrate a...
Application: TRPV4 agonist
CAS 942206-85-1
MW: 655.6 D
Purity: >98%
Format: Crystalline Solid
From 32.00€
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Angiotensin II (human)
Angiotensin II (human)

Item number: Cay17150-25

Angiotensin II is a peptide hormone known best as a vasoconstrictor with central roles in chronic hypertension, heart failure, and stroke. It is an octapeptide typically generated by the removal of two residues from angiotensin I by angiotensin-converting enzyme (ACE). Angiotensin II is a ligand for at least two distinct receptors, AT1 and AT2, each evoking distinct...
Application: Peptide hormone
CAS 4474-91-3
MW: 1046.2 D
Purity: >90%
Format: Crystalline Solid
From 24.00€
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BIBR 1532
BIBR 1532

Item number: Cay16608-1

BIBR 1532 is a mixed-type non-competitive inhibitor of telomerase (IC50 = 93 nM) that has little effect on several mammalian DNA and RNA polymerases, bacterial DNA helicase, or HIV-1 reverse transcriptase. It specifically targets the telomerase reverse transcriptase catalytic subunit, TERT. Through its effects on telomerase, BIBR 1532 induces senescence or apoptosis in...
Application: Telomerase / TERT inhibitor
CAS 321674-73-1
MW: 331.4 D
Purity: >95%
Format: Crystalline Solid
From 32.00€
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2-Oleoyl Glycerol
2-Oleoyl Glycerol

Item number: Cay16537-5

2-Oleoyl glycerol (2-OG) is a natural monoacylglycerol with an 18:1 oleoyl group at the sn-2 position of glycerol. 2-OG, like 2-arachidonoyl glycerol (2-AG, Cay-62160), is metabolized by monoacylglycerol lipase, but, unlike 2-AG, it is not metabolized by cyclooxygenases or lipoxygenases. 2-OG is an agonist of GPR119 (EC50 = 2.5 µM), stimulating the release of glucagon-like...
Application: GPR119 agonist
CAS 3443-84-3
MW: 356.5 D
Purity: >98%
Format: Solution
From 32.00€
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2-Oleoyl Glycerol
2-Oleoyl Glycerol

Item number: Cay16537-25

2-Oleoyl glycerol (2-OG) is a natural monoacylglycerol with an 18:1 oleoyl group at the sn-2 position of glycerol. 2-OG, like 2-arachidonoyl glycerol (2-AG, Cay-62160), is metabolized by monoacylglycerol lipase, but, unlike 2-AG, it is not metabolized by cyclooxygenases or lipoxygenases. 2-OG is an agonist of GPR119 (EC50 = 2.5 µM), stimulating the release of glucagon-like...
Application: GPR119 agonist
CAS 3443-84-3
MW: 356.5 D
Purity: >98%
Format: Solution
From 32.00€
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AGK7
AGK7

Item number: Cay16152-5

AGK2 (Cay-13145) is a cell-permeable, selective inhibitor of SIRT2 (IC50 = 3.5 µM) that minimally affects either SIRT1 or SIRT3 at 10-fold higher levels. AGK7 is an inactive control to be used in experiments with AGK2. It differs from AGK2, structurally, only in the position of nitrogen in the quinoline group. AGK7 has IC50 values greater than 50 µM on SIRT1 and SIRT2 and...
Application: Cell-permeable, selective SIRT2 inhibitor AGK2 inactive control
CAS 304896-21-7
MW: 434.3 D
Purity: >95%
Format: Crystalline Solid
From 60.00€
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