Products from MONOSAN

Placental alkaline phosphatase (PLAP) is a membrane-associated sialoglycoprotein enzyme normally present at high concentration in syncytiotrophoblasts within the placenta during the third trimester of gestation. The expression of PLAP was originally thought to be restricted to term placenta but a human PLAP-like...

MONX11130 is recommended for the detection of CD123 in normal and neoplastic tissues, particularly to aid in the identification of plasmacytoid dendritic cell neoplasms. Protein function: This is a receptor for interleukin-3. [The UniProt Consortium] Protein function: This is a receptor for interleukin-3. [The...

MON1019 is an alpha chain integrin that is expressed as heterodimer non-covalently associated with CD18. CD11b is also designated as CR3, Mac-1, Mo-1 in integrin alphaM subunit and has a molecular weight of 165-170 kDa. The protein mediates PMN and monocytes adherence to endothelium and subsequently PMN...

CD11b (integrin alpha-M, ITGAM, integrin alpha-X, ITGAX) is a 165 kDa adhesion molecule that associates non-covalently with integrin beta-2 (CD18). The CD11b/CD18 heterodimeric complex is also known as integrin alpha-M beta-2, Mac-1, and CR3 (complement receptor 3). CD11b is expressed on the surface of...

MON1023 specifically reacts with CD1a, an MHC like transmembrane glycoprotein of 49 kDa, that presents lipid molecules and is non-covalently associated with beta2-microglobulin. The antigen is strongly expressed on cortical thymocytes and dendritic cells and disappears at later stages of maturation. Protein...

MON1025 reacts with CD11a, a transmembrane molecule with 1145 amino acid residues and a MW of 180 kDa. CD11a is expressed on lymphocytes, granulocytes, monocytes and macrophages. Levels on memory T-cells tend to increase. CD11a plays a key role in mediating leukocyte adhesion to endothelium during inflammatory...

MON1027 reacts with CD15 (220 kDa). CD15 is present on >95% of granulocytes including neutrophils and eosinophils and to a lesser degree on monocytes. CD15 is further expressed in Reed-Sternberg cells in classic Hodgkin's disease. CD15 is occasionally expressed in large cell lymphomas of both B and T phenotypes. It...

MON1029 reacts with Human CD16. Mab MEM-154 reacts with epitope residing in proximity to FG loop (probably BC or C'E loop). Mab recognizes a polymorphism of CD16a (NK cells form) and reacts well with granulocyte form (CD16b) of all subjects. Protein function: Receptor for the Fc region of immunoglobulins gamma. Low...

MON1030 reacts with human CD26 (Dipeptidyl peptidase IV), a 110 kDa protein which occurs in the cell membrane of T-lymphocyte and is upregulated after activation. CD26 is also present on endothelial cells and also expressed on activated B-cells and natural killer cells and abundantly on epithelia. CD26 is implicated...

MON 1031A reacts with beta2-microglobulin (beta2M) associated with cell-surface MHC Class I molecules and other membrane antigens as well as with soluble beta2-microglobulin. Beta2M is a 12 kDa Ig like glycoprotein expressed on lymphocytes, thymocytes, monocytes, granulocytes, platelets, endothelial cells and...

MON1033 reacts with a protein determinant of the extra cellular domain of the human EGFR, and does not cross react with EGFR from murine cells. The antibody shows binding competition with EGF. The antibody reacts in immunoprecipitation with the functional EFR protein-tyrosine kinase complex. Protein function:...

MON1034 recognizes a 150/130 kD receptor for fibronectin, (VLA-alpha-5 protein from the integrin superfamily of antigens). The antibody reacts with platelets, lymphocytes, monocytes and most cell lines including K562 and U937. Protein function: Integrin alpha-5/beta-1 (ITGA5:ITGB1) is a receptor for fibronectin and...